ISSN:
0749-1581
Keywords:
1H NMR
;
Paramagnetic 1H NMR
;
Natural abundance 2H NMR
;
19F NMR
;
Iron(II) cysteine-peptide complex
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An Fe(II) complex with Z-Ala-Cys—Pro—Leu—Cys—Gly—NH—C6H4—m—F (Z = benzoxylcarbonyl) having an invariant bidentate peptide ligand, Cys—K—Y—Cys, in rubredoxins was synthesized. The contact-shifted 1H, 2H and 19F NMR signals of (Et4N)2[Fe(Z—Ala—cys—Pro—Leu—cys—Gly—NH—C6H4—m—F)2] (1) in acetonitrile-d3 or acetonitrile at 30°C indicate the existence of two isomers (δ and λ) in the solution of bidentate complex 1 with different orientations of the bidentate peptide ligand to a tetrahedral Fe(II) ion. A novel tetradentate cysteine-containing peptide ligand, cis-1,2-cyclohexylene(CO—Ala—Cys—Pro—Leu—Cys—Gly—NH—C6H4—m—F)2, is designed by energy minimum calculations and synthesized. Its Fe(II) complex, (Et4N)2[Fe(cis-1,2-cyclohexylene(CO-Ala-cys-Pro-Leu-cys-Gly-NH-C6H4-m-F)2)], showed only set of contact-shifted 1H, 2H and 19F NMR signals of Cys CβH2 due to the preferable formation of the δ isomer.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260311309
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