ISSN:
1530-0358
Keywords:
Familial polyposis
;
Multiple polyposis
;
Polyposis coli
;
Cancer
;
DNA ploidy
;
Flow cytometry
;
Aneuploidy
;
Polyps
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more likely to be advanced and had a significantly worse prognosis (17 percent vs.76 percent 5-year survival;P 〈0.01). Only 4 of 20 polyps studied were nondiploid. There was no association between tumor and polyp ploidy. All nondiploid polyps were found in patients with synchronous diploid cancers. Patients with nondiploid polyps were more likely to be older and have more advanced tumors than those with diploid polyps. DNA ploidy abnormalities seem to occur with the same frequency in polyposis coli as in the nonpolyposis population, and tumor ploidy correlates with prognosis
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02050070
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