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  • 1
    Electronic Resource
    Electronic Resource
    Effects of Nerve Growth Factor antiserum on peripheral unmyelinated nerve fibers (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 288-298 
    Details
    ISSN: 1432-0533
    Keywords: Nerve Growth Factor ; Peripheral Nerve Fibres ; Schwann Cells ; Electron Microscopy ; Phase Contrast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nerve Growth Factor (NGF) antiserum causes neuronal loss in the sympathetic ganglia of newborn rats. Pre and post ganglionic sympathetic fibers from eleven such animals and eight controls were studied by phase contrast and electron microscopy. Quantitative techniques were applied to the study of different parameters of the axons and Schwann cells. Treated animals showed only 24% of the axonal population of controls and 34% of Schwann cells. This fiber loss was non-selective, affecting all fiber sizes. Schwann cells from treated animals enclosed fewer axons than normal and some contained none. Contrary to what is seen following transection of an unmyelinated nerve, regenerative axonal sprouting was not observed during the 6 week period studied. Schwann cell processes were elongated and unfolded, frequently engulfing bundles of collagen. NGF antiserum experiments provide a tool for the study of axonal and Schwann cell behaviour after neuronal loss avoiding the disadvantages of the traumatic disruption of neural architecture that results from experimental surgical lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691747
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Angiogenesis in malignant primary and metastatic brain tumors (2000)
    Springer
    Journal of neurology 247 (2000), S. 597-608 
    Details
    ISSN: 1432-1459
    Keywords: Key words High-grade glioma ; Cerebral metastasis ; Leptomeningeal metastasis ; Angiogenesis ; Blood-brain barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with malignant primary and metastatic brain tumors have a poor prognosis, despite developments in diagnostic and therapeutic modalities. Therefore in the past decade a search for new therapeutic possibilities has started. The inhibition of angiogenesis, the sprouting of new capillaries from preexisting vasculature, which is an absolute requirement for the growth of tumors beyond a size of a few cubic millimeters, is one of the most promising approaches with which to influence tumor growth. This review focuses on the critical role of angiogenesis in the development of normal brain and the blood-brain barrier. We discuss the importance of angiogenesis in the formation of malignant brain tumors and in blood-brain barrier function in these tumors and possible consequences of altered blood-brain barrier properties for antiangiogenic therapy. Furthermore, results of current clinical trials with antiangiogenic drugs are reviewed, and clinical perspectives of antiangiogenic therapy in malignant brain tumors are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150070128
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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