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  • 1
    Electronic Resource
    Electronic Resource
    Clinical Study of glucose metabolism during partial gastrectomy (1987)
    Springer
    Journal of anesthesia 1 (1987), S. 82-87 
    Details
    ISSN: 1438-8359
    Keywords: Blood glucose ; Glucose loading ; Insulin ; Epidural anesthesia ; Upper abdominal surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma glucose, insulin, glucagon, growth hormone (GH) and cyclic-AMP (C-AMP) were measured in 14 patients undergoing partial gastrectomy under 5 g/hr glucose loading. Seven patients received general anesthesia (GOF; Group G) and the other seven, GO + epidural anesthesia (analgesia Th4–L1; Group E). Blood glucose increased in both groups, although it remained consistently lower in Group E than in Group G. Serum IRI and IRI/glucose ratio appeared consistently higher in Group E than in Group G and a significant difference was found between the two groups at the early period of surgery. The changes in plasma glucagon and GH were found independent of those in glucose. Cyclic-AMP was also consistently higher in Group G than in Group E and a significant difference was observed at the end of anesthesia. These results suggest that epidural anesthesia with 5 g/hr glucose loading may facilitate insulin release from the islet and peripheral blood uptake particularly during the early period of surgery while many other factors such as GH, cortisol and vagal stimulation seemed to be involved in the later period of surgery. (Ogata M et al.: Clinical study of glucose metabolism during partial gastrectomy; comparison between epidural and general anesthesia. J Anesth 1: 82–87, 1987)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054070010082
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The changes in arterial keton bodies during upper abdominal surgery (1990)
    Springer
    Journal of anesthesia 4 (1990), S. 131-137 
    Details
    ISSN: 1438-8359
    Keywords: Arterial keton body ratio ; Insulin ; Β-Hydroxybutyrate ; Upper abdominal surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between the arterial keton body ratio (AKBR: acetoacetate/Β-hydroxybutyrate) and the plasma hormone activities were studied under a general anesthesia using enflurane group (group G) and a GO + Epidural group (group E) with continuous glucose loading (10 g·hr−1) during partial gastrectomy. In both groups, the AKBR increased significantly during the operation. The plasma insulin activity was significantly positively correlated with the AKBR and it was negatively correlated with log (Β-hydroxybutyrate) in both groups. We could not find any significant difference of the AKBR between group G and group E. Our results indicate that the plasma insulin activity affects the arterial keton body ratio and that the AKBR must be evaluated considering the plasma hormone activity, especially insulin activity during the operation. (Ogata M, Obata K, Matsumoto et al.: The changes in arterial keton bodies during upper abdominal surgery. J Anesth 4: 131–137, 1990)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054000040131
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    C-type natriuretic peptide inhibits rat mesangial cell proliferation by a phosphorylation-dependent mechanism (1997)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 357 (1997), S. 70-76 
    Details
    ISSN: 1432-1912
    Keywords: Key words C-type natriuretic peptide ; Protein kinase ; Mesangial cell ; Interleukin-1 ; Interleukin-6 ; Angiotensin II ; Platelet derived growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the effects of C-type natriuretic peptide (CNP) on rat cultured mesangial cell proliferation. (1) Exposure to CNP (10 nM–1 μM for 72 h) inhibited [3H]thymidine incorporation into mesangial cells in a concentration-dependent manner. Atrial natriuretic peptide (1 nM–1 μM), a peptide related to CNP, also decreased [3H]thymidine incorporation into these cells in a concentration-dependent manner. (2) Both CNP (10 nM-1 μM) and atrial natriuretic peptide (10 nM-1 μM) also decreased mesangial cell number. (3) The cyclic GMP analog, 8-bromo-cyclic GMP (100 μM and 1 mM), mimicked the inhibitory effects of CNP and atrial natriuretic peptide on [3H]thymidine incorporation into mesangial cells, whereas inhibitors of protein kinase C, protein kinase A, and protein kinase G reduced the effect of both natriuretic peptides. Moreover, the phoshpatase inhibitor, calyculin A, increased [3H]thymidine incorporation into mesangial cells. (4) CNP and atrial natriuretic peptide decreased interleukin-1-, interleukin-6-, platelet derived growth factor-, angiotensin II-induced [3H]thymidine incorporation into mesangial cells. These results suggest that CNP exerts inhibitory effects on mesangial cell proliferation and that this effects depend on protein phosphorylation pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005140
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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