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  • Angiotensin-converting enzyme inhibitors  (1)
  • Antisense Oligodeoxynucleotide  (1)
  • 1
    Electronic Resource
    Electronic Resource
    GABA-Transaminase Antisense Oligodeoxynucleotide Modulates Cocaine- and Pentylenetetrazol-Induced Seizures in Mice (1999)
    Springer
    Metabolic brain disease 14 (1999), S. 253-263 
    Details
    ISSN: 1573-7365
    Keywords: Antisense Oligodeoxynucleotide ; Seizure ; GABA-Transaminase ; Cocaine ; Pentylenetetrazol ; GABA Antisense oligodeoxynucleotide ; Seizure ; GABA-Transaminase ; Cocaine ; Pentylenetetrazol ; GABA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mechanism of action of many anticonvulsive agents is to increase the function of the GABAergic system. Inhibition of GABA-Transaminase (GABA-T), the degradative enzyme for GABA, increases GABA levels in the brain. In this study, antisense oligodeoxynucleotides (ASO) targeted at the start codon region of GABA-Transaminase mRNA were used to modify seizure activity. Mice were treated, by intracerebroventricular injection, with antisense oligos or appropriate controls. At various times after treatment, the animals were challenged with cocaine (70 mg/kg, i.p.) and observed for seizure activity. At 15 hours after treatment, 1.152 and 1.44 nmol antisense oligo blocked cocaine-induced seizures. There was no effect of antisense oligo 8 or 36 hours after treatment. In addition, treatment with 7.2 nmol antisense oligo prevented pentylenetetrazol-induced seizures. These data demonstrate the modulation of seizure threshold using antisense oligodeoxynucleotides to GABA-T.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020737125843
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperkalemia in hospitalized patients (2000)
    Springer
    International urology and nephrology 32 (2000), S. 177-180 
    Details
    ISSN: 1573-2584
    Keywords: Angiotensin-converting enzyme inhibitors ; Hyperkalemia ; Potassium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Evaluate the prevalence of hyperkalemia(potassium 〈 5.5 mmol/l) in hospitalized patientsnot on dialysis, as well as the association ofmedications, impaired renal function and comorbidconditions with hyperkalemia.Design: A retrospective case-control method.Setting: A tertiary care teaching hospital.Patients: Hyperkalemic adults not on dialysis withage and sex matched controls.Interventions: None.Main outcome measures: The use of medicationsassociated with hyperkalemia and renal function usinga calculated creatinine clearance were compared in thehyperkalemic and control groups.Results: 35 adult patients with hyperkalemia who werenot receiving dialysis were identified, with aprevalence in the hospitalized population of 3.3%.The hyperkalemic patients were older than the generalhospital population (p 〈 0.05). Compared withcontrols, hyperkalemic patients: had a lowercreatinine clearance (p 〈 0.05), were more likely tobe taking angiotensin-converting enzyme inhibitors (p 〈 0.05), and had an increased frequency of diabetesmellitus (p 〈 0.001). All of the control patientssurvived their hospitalization, but the mortality rate in the hyperkalemic group was 17% (p 〈 0.0001). Noneof the deaths were directly attributable to hyperkalemia.Conclusions: Hyperkalemia is more frequent in olderpatients and is usually mild. Hyperkalemia isassociated with diabetes mellitus, diminished renalfunction and the use of angiotensin-converting enzymeinhibitors. An elevated serum potassium level in ahospitalized patient may be a marker for asignificantly increased risk of death, which is due tounderlying medical problems and is not a consequenceof the hyperkalemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007135517950
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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