ISSN:
1434-0879
Keywords:
Urothelial carcinoma
;
Animal experiment
;
N-butyl-n-butanol-4-nitrosamine
;
Chemical carcinogenesis
;
X-ray analytical measurement
;
Tumor markers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The aim of this study was to analyseN-butyl-n-butanol-4-nitrosamine (BBN)-induced alterations of the urothelium in rats concerning its content of phsphorus, sulphur, chlorine, potassium and calcium using electron microscopic X-ray microanalysis (REM analysis). The following histopathological findings of the bladder mucosa were discovered after exposure to BBN: normal urothelimm (n=36); focal epithelial proliferations (n=12) following 6–12 weeks' exposure; epithelial hyperplasia (n=8) after urothelial carcinoma (n=4) following 12 weeks' exposure. The observed phosphorus/sulphur and phosphorus/calcium ratios based on REM analysis did not show any statistical correlation with the morphological changes classified by light microscopy. Our data do not support the hypothesis raised by other investigators that an increase in phosphorus content or phosphorus/sulphur or phosphorus/calcium ratio could indicate early neoplastic transformations of urothelial cells as “tumor markers”.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00571845
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