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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 132 (1997), S. 255-260 
    ISSN: 1432-2072
    Keywords: Key words RU24969 ; 5HT1A receptors ; 5HT1B receptors ; Anpirtoline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioural profiles of the mixed 5HT1A/B agonist RU24969 and the more selective 5HT1B agonist anpirtoline were compared. Both compounds induce an increase in activity as measured in photocell activity cages. The behaviours displayed by the rats receiving each treatment differed markedly, with RU24969 inducing flat body posture and circling of the cage perimeter (1.25−10 mg/kg SC), whereas anpirtoline increased ambulation characterised by a hopping motion (1.25−5.0 mg/kg SC). The effects of RU24969 were attenuated by both the 5HT1A antagonist WAY100635 (0.03−1.25 mg/kg SC) and the 5HT1B/D antagonist GR127935 (1.0−5.0 mg/kg SC). Anpirtoline-induced behaviour was attenuated by GR127935 across the same dose range but was largely unaffected by WAY100635 even at doses above those which had blocked the effects of RU24969. Coadministration of the selective 5HT1A agonist 8-OH-DPAT (0.03−1.25  mg/kg SC) with anpirtoline (2.5 mg/kg) induced a dramatic increase in locomotor activity and a behavioural syndrome identical to that produced by RU24969. Thus it would appear that a synergistic effect of stimulation of both 5HT1A and 5HT1B receptors underlies the behavioural effects of RU24969, while anpirtoline acts mainly via stimulation of 5HT1B receptors only.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-9680
    Keywords: Calliandra calothyrsus ; forage ; leguminous fodder ; manure ; Napier grass (Pennisetum purpureum)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract A cross-sectional survey on 41 farms followed by six weeks monitoring of dairy cattle feeding on ten smallholder dairy farms in central Kenya was conducted to investigate the use, availability and quality of dry season feed resources. Fodder production was largely from Napier grass (Pennisetum purpureum) grown on small plots and contour strips where it acts both as a fodder source as well as a biological barrier to soil erosion. There is a need to broaden the choice of fodder crops on such farms to provide a wide range of harvesting management options and to avoid total loss in case of pest or disease outbreaks. Intercropping of Napier grass with leguminous fodder trees could boost the quantity and quality of herbage production especially during the dry season. Roughage from a variety of sources was utilised during the dry season in addition to Napier grass. Among the herbages, leguminous feeds had the lowest potential dry matter degradability while weeds harvested from cropland and roadsides had the highest. Energy and protein intake from the roughage fed to grade dairy cattle during the dry season may be insufficient to meet the requirements of these animals due to the high levels of fibre concentration (acid detergent fibre and neutral detergent fibre (ADF and NDF)) in them. It is recommended that the scope for alternative sources of improved roughage such as Napier/calliandra mixtures, to boost the energy, protein and overall dry matter provision on the farms should be investigated further.
    Type of Medium: Electronic Resource
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