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  • 1
    Electronic Resource
    Electronic Resource
    Evidence for sequential degeneration of the neurons in the intermediate zone of the spinal cord in amyotrophic lateral sclerosis: a topographic and quantitative investigation (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 343-349 
    Details
    ISSN: 1432-0533
    Keywords: ALS ; Spinal cord ; Propriospinal neuron ; Anterior horn cell ; Quantitative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the degenerating mechanism of the neurons in the intermediate zone of the spinal cord in classical amyotrophic lateral sclerosis (ALS), the spinal neurons in a patient with ALS, whose muscular strength was fairly well preserved up to death, were examined quantitatively and topographically, and compared with the data of advanced ALS patients and age-matched control subjects reported previously. In advanced ALS patients, anterior horn cells completely disappeared and the medium-sized (nuclear area; 71–150 μm2) and large (nuclear area; greater than 151 μm2) neurons in the intermediate zone were severely reduced. In the present case, however, the loss of anterior horn cells was severe but the degree was not equal to that of advanced ALS patients, and the neurons in the intermediate zone were quite well preserved. The finding indicates that the primary degeneration may occur in the anterior horn cells and the neurons in the intermediae zone degenerate sequentially in the spinal gray matter in ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687368
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  • 2
    Electronic Resource
    Electronic Resource
    Three new mutations in the hepatocyte nuclear factor-1α gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization (1999)
    Springer
    Diabetologia 42 (1999), S. 621-626 
    Details
    ISSN: 1432-0428
    Keywords: Keywords MODY ; HNF-1α ; insulin ; arginine ; mutation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Mutations in the hepatocyte nuclear factor-1α gene are a common cause of the type 3 form of maturity-onset diabetes of the young. We examined the clinical features and molecular basis of hepatocyte nuclear factor-1α (HNF-1α) diabetes. Methods. Thirty-seven Japanese subjects with early onset Type II (non-insulin-dependent) diabetes mellitus and 45 with Type I (insulin-dependent) diabetes mellitus were screened for mutations in this gene. Functional properties of mutant HNF-1α were also investigated. Results. Three new mutations [G415R, R272C and A site of the promoter ( + 102G-to-C)] were found. Insulin secretion was impaired in the three subjects. Insulin and glucagon secretory responses to arginine in the subject with the R272C mutation were also diminished. Molecular biological studies indicated that the G415R mutation generated a protein with about 50 % of the activity of wild-type HNF-1α. The R272C mutation had no transactivating or DNA binding activity and acted in a dominant negative manner. The + 102 G-to-C mutation in the A site of the promoter activity was associated with an increase in promoter activity and it had 42–75 % more activity than the wild-type sequence. Conclusion/interpretation. Mutations in the HNF-1α gene may affect the normal islet function by different molecular mechanisms. [Diabetologia (1999) 42: 621–626]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051204
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Nafion-like thin film plasma-polymerized from perfluorobenzene/SO2 mixture (1989)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 27 (1989), S. 3495-3501 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Plasma polymerization of perfluorobenzene/sulfur dioxide (PFB/SO2) mixture was investigated by elemental analysis, infrared spectroscopy, and XPS. Plasma polymer films like Nafion were obtained from the plasma polymerization of PFB/SO2 mixture. The plasma polymerization deposited fluoropolymers with sulfur moieties including sulfonate and sulfonic acid groups. The elemental composition, F/C, and S/C atomic ratio of the formed plasma polymers were 0.65-0.67 and 0.24-0.27, respectively, which were independent of the starting mixture composition. The polymers showed cation-exchange ability of which the capacity was 0.49 meq/g polymer, and initiated the polymerization of pyrrole.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1989.080271026
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    Paper (German National Licenses)
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