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  • 1
    Electronic Resource
    Electronic Resource
    Effect of protein kinase C activation and depletion on insulin stimulation of glycogen synthesis in cultured hepatoma cells (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 34-37 
    Details
    ISSN: 1420-9071
    Keywords: Glycogen synthesis ; insulin ; protein kinase C ; Zajdela hepatoma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Insulin stimulation of glycogen synthesis was nearly abolished in hepatoma cells shortly treated with 4 ß-phorbol 12 \-myristate, 13 α-acetate (protein kinase C activation) but remained unmodified in cells chronically treated with the phorbol ester (protein kinase C depletion). Thus, although exogenous activation of protein kinase C results in an inhibition of insulin action, protein kinase C depletion has no influence on this process. The results suggest that, in hepatoma cells, no endogenous activation of protein kinase C may occur in response to the signal triggered by insulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960235
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in glycosaminoglycan sulfation and protein kinase C subcellular distribution during differentiation of the human colon tumor cell line Caco-2 (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 588-591 
    Details
    ISSN: 1420-9071
    Keywords: Differentiation ; glycosaminoglycan sulfation ; protein kinase C ; phorbol esters ; Caco-2 cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary During the spontaneous differentiation (day 5 to day 15 of the culture) of Caco-2 cells, the sulfation of cell layer glycosaminoglycans increased, whereas protein kinase C activity was concomitantly redistributed from the membrane to the cytosol. The protein kinase C activators, 4β-phorbol 12β-myristate, 13α-acetate and 1,2-dioctanoyl-glycerol inhibited glycosaminoglycan sulfation. By contrast, 4α-phorbol 12, 13 didecanoate was ineffective. These results suggest that membrane-bound PKC may exert a modulatory effect on glycosaminoglycan sulfation, and this effect is gradually attenuated as Caco-2 cell differentiation progresses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990515
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The persistent Müllerian duct syndrome: A rare cause of cryptorchidism (1993)
    Springer
    European journal of pediatrics 152 (1993), S. S76 
    Details
    ISSN: 1432-1076
    Keywords: Anti-Müllerian hormone (AMH) ; Müllerian-inhibiting substance (MIS) ; Intersex ; Male pseudohermaphroditism ; Uterus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The persistent Müllerian duct syndrome is characterized by the retention of Müllerian derivatives in patients otherwise normally virilized. Clinically, the persistence of uterus and tubes leads either to cryptorchidism or inguinal hernia, depending on whether or not the Müllerian derivatives can be mobilized during testicular descent. The condition is usually discovered at surgery, however preoperative sonography could allow the diagnosis to be made preoperatively. The molecular basis of the persistent Müllerian duct syndrome is heterogeneous, and is reflected by wide variations in the serum concentration of anti-Müllerian hormone. Some cases are apparently due to end-organ resistance, and are associated with normal serum levels of the hormone. Others, characterized by absent or low hormone concentrations, can be explained by mutations of the gene coding for anti-Müllerian hormone, which are distributed along the whole length of the coding region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02125444
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Further evidence for abnormal protein kinase C regulation of macromolecule secretion in fibroblasts from cystic fibrosis patients (1990)
    Springer
    Bioscience reports 10 (1990), S. 563-572 
    Details
    ISSN: 1573-4935
    Keywords: cystic fibrosis ; protein kinase C ; glycoconjugate secretion ; phorbol esters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In comparison to skin fibroblasts from normal subjects, those from patients with cystic fibrosis (CF): (1) bound [20-3H] phorbol 12,13-dibutyrate (PDBu) with a higher affinity (Kd=25.8 vs 12.8 nM respectively) but expressed a similar number of total phorbol ester binding sites (about 2.5 pmol PDBu bound/mg of protein); (2) exhibited a faster and higher response to 4β-phorbol 12β-myristate 13α-acetate (PMA) for the stimulation of [35S]-labelled glycoconjutate release, but were equally sensitive to the synergistic effect of A23187 on this process; and (3) secreted glycoconjugates with similar [35S]-sulfate and [14C]-leucine to [14C]-glucosamine labelling ratios. Taken together, these results provide further evidence for abnormal protein kinase C (PKC) regulation of macromolecule secretion in CF disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116617
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    Paper (German National Licenses)
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