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  • Thyrotropin receptor  (2)
  • Anti-insulin  (1)
  • Apical root resorption  (1)
  • Autoimmunity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 68 (1990), S. R15-R17 
    ISSN: 0303-7207
    Keywords: Molecular variant ; Thyroid ; Thyrotropin receptor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0303-7207
    Keywords: Autoimmunity ; CHO cells ; Graves' disease ; Thyrotropin receptor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Anti-insulin ; IgG sub-classes ; monoclonal antibodies ; enzyme linked immunosorbant assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunochemical micromethod was designed to estimate total IgG and IgG sub-classes of anti-insulin antibodies in immunized diabetic patients. Insulin, immobilized on a solid phase, was allowed to react with serum samples containing anti-insulin antibodies. Bound anti-insulin IgG interacted with mouse monoclonal antibodies specific for total IgG or for each IgG isotype. The fixation of mouse monoclonal antibody was subsequently detected using a horseradish peroxidase-conjugated rabbit anti-mouse IgG in the presence of a chromogenic substrate. The test was standardized by an immunocapture assay utilizing coated rabbit anti-human IgG and known concentrations of purified human myelomatous proteins of each sub-class. Results of anti-insulin IgG and anti-insulin IgG sub-classes assay could therefore be expressed in ng equivalent myelomatous proteins per ml of serum. Analysis of serum samples from 24 insulin-immunized diabetic patients revealed a quasi absence of IgG2 anti-insulin antibodies and an increase of the relative abundance of the other three anti-insulin IgG isotypes. In our series, anti-insulin IgG1 was predominant, followed by IgG3 (in 17/24 patients) or IgG4 (in 7/24). Insulin immunization was deduced to be of polyclonal nature, the isotype pattern of which is not representative of the relative proportion of IgG sub-classes in whole normal serum.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1615-6714
    Keywords: Apical root resorption ; Randomized clinical trial ; Fixed appliances ; Dental radiography ; Radiographic image ; Apikale Wurzelresorption ; Randomisierte klinische Studie ; Festsitzende Apparaturen ; Dentales Röntgen ; Radiologische Bildverstärkung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ziel dieser Studie war es, das Auftreten und das Ausmaß von apikalen Wurzelresorptionen nach einer Behandlung mit vollprogrammierter Edgewise-Apparatur (FPA) bzw. mit partiell programmierter Version (PPA) in einer randomisierten klinischen Untersuchung röntgenologisch zu vergleichen. Zwei Patientengruppen mit einer Klasse-II-Okklusionsanomalie wurden kieferorthopädisch behandelt. Die Behandlungsmethode wurde mittels eines Computerprogramms randomisiert bestimmt. Während der Behandlung mit festsitzender Apparatur wurde eine Gruppe nach den Prinzipien der Straight-wire-Apparatur behandelt (FPA; n=32), während die andere Gruppe mit konventioneller Edgewise-Apparatur (PPA, n=29) behandelt wurde. Die Behandlungszeit wurde erfaßt. Vor und nach der aktiven Behandlung mit festsitzender Apparatur wurden Röntgenaufnahmen der oberen Schneidezähne mit der Halbwinkeltechnik angefertigt. Um eventuell unterschiedlliche Einfallswinkel bei der Aufnahme zu korrigieren, wurden die Röntgenaufnahmen digital rekonstruiert. Auftreten und Ausmaß von Wurzelresorptionen wurden analysiert. Die durchschnittliche Behandlungszeit betrug 1,8 Jahre für die Behandlung mit FPA und 1,6 Jahre für die Behandlung mit PPA. Die durchschnittliche Wurzelverkürzung betrug 8,2% bei den mit FPA behandelten Patienten und 7,5% bei den mit PPA behandelten Patienten. Zwischen den beiden Gruppen konnten keine statistisch signifikanten Unterschiede bei Abschluß der aktiven Behandlung festgestellt werden. Im Durchschnitt traten bei 75% der mit FPA behandelten Patienten und bei 55% der mit PPA behandelten Patienten apikale Wurzelresorptionen auf. Die statistische Auswertung zeigte keine signifikanten Unterschiede. Wir kamen zu dem Schluß, daß sowohl das Auftreten als auch der Grad an Wurzelresorptionen unabhängig von den Behandlungsmethoden war, die in dieser Studie verwendet wurden.
    Notes: Summary The purpose of this paper was to compare radiographically the prevalence and degree of apical root resorption after treatment with a fully programmed edgewise appliance (FPA) and a partly programmed edgewise appliance (PPA) in a randomized multipractice clinical trial. Two groups of patients with Class II malocclusions were treated orthodontically. The type of treatment was randomly assigned by a computer program. During fixed appliance therapy, one group was treated according to the precepts of the straight wire concept (FPA; n=32) while the other was treated with conventional full edgewise mechanics (PPA; n=29). Treatment times were recorded. Radiographs of the maxillary incisors were made before and after active treatment with fixed appliance using the bisecting angle technique. To correct for different projecting angles the pairs of radiographs were digitally reconstructed. The prevalence and degree of root resorption were assessed. The mean treatment time was 1.8 years and 1.6 years for treatment with FPA and PPA, respectively. The mean amount of loss of tooth length was 8.2% for the patients treated with FPA and 7.5% for the patients treated with PPA. No statistically significant differences could be assessed between both groups at the end of active treatment. The mean prevalence of apical root resorption was 75% for the patients treated with FPA and 55% for the patients treated with PPA. Statistical evaluation showed no significant differences. We concluded that the prevalence and degree of root resorption is independent of the appliances as used in this study.
    Type of Medium: Electronic Resource
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