ISSN:
1432-0851
Keywords:
Chronic myelogenous leukaemia
;
Cytokines
;
T cell clones
;
Anti-leukaemia cytotoxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary T cell clones derived from a chronic myelogenous leukaemia (CML) patient during interferon α (IFNα, Wellferon) biotherapy preferentially lysed autologous rather than allogeneic CML target cells in an apparently MHC-unrestricted fashion, but also lysed bone marrow cells from certain normal donors regardless of whether or not they shared HLA antigens with the patient. Although T cell clones inhibited both CML and normal bone marrow in the colony-forming assay, they blocked proliferation of CML cells more efficiently than bone marrow cells. This inhibitory effect was mediated at least in part by the tumour necrosis factor α (TNFα) and IFNγ secreted by the clones. Antisera to these cytokines partially prevented inhibition. Involvement of additional factors is also suggested in blocking CML cell proliferation because this was not 100% inhibited even by a combination of TNFα and IFNγ. In addition, most clones failed strongly to block the proliferation of normal bone marrow cells, which were susceptible to inhibition by these cytokines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01742529
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