ISSN:
1432-1459
Keywords:
Key words Parkinson’s disease
;
Anti-saccades
;
Memory-guided
;
saccades
;
Chronic stimulation
;
Posteroventral pallidum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Chronic electrical stimulation of the posteroventral internal pallidum, a recently developed treatment option in advanced Parkinson’s disease (PD), improves bradykinesia, rigidity and medication-induced dyskinesia. Apart from disturbances of the somatic motor system, PD is also characterized by disturbances of saccadic eye movements with hypometric and delayed internally guided saccades. We examined these internally guided eye movements (memory-guided and anti-task saccades) in a patient with bilaterally implanted stimulation electrodes, when stimulation was turned on and off. The electrical stimulation not only improved the bradykinesia and rigidity, but also the internally guided saccades by shortening the latency of the anti-saccades and increasing the gain of the memory-guided saccades. This finding supports the idea that the oculomotor pathways through the basal ganglia are organized like the somatic motor pathways and that stimulation of the posteroventral pallidum influences both.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004150050186
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