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  • Anti-thoracic duct lymphocyte globulin  (1)
  • DNA synthetic phase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Kinetics of megakaryocyte progenitor cells in idiopathic thrombocytopenic purpura (1990)
    Springer
    Annals of hematology 61 (1990), S. 303-306 
    Details
    ISSN: 1432-0584
    Keywords: ITP ; CFU-Meg ; DNA synthetic phase ; Megakaryocyte ; Platelet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The number and proliferative state of megakaryocyte progenitor cells (CFU-Meg) were compared between 13 patients with idiopathic thrombocytopenic purpura (ITP) and hematologically normal controls. The mean frequency of CFU-Meg assayed by the plasma clot method was 27.8 ± 12.2 (± SD)/2×105 bone marrow light-density cells for the ITP patients, which did not differ significantly from the control value of 31.9 ± 16.1. The percentage of CFU-Meg in DNA synthesis estimated by the3H-thymidine suicide technique was 41.3% ± 9.2% in ITP, which was significantly greater than the control value of 27.1% ± 7.4% (P 〈 0.01). The megakaryocyte counts for histological sections prepared from bone marrow aspirates from the ITP patients and controls were 34.5 ± 8.5/mm2 and 11.2 ± 5.8/mm2, respectively, with the difference being highly significant (P 〈 0.001). These results suggest that increased cycling activity in a quantitatively unchanged CFU-Meg pool may lead to increased megakaryocytes in the bone marrow of ITP patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732882
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-thoracic duct lymphocyte globulin stimulates human megakaryocytopoiesis in vitro (1990)
    Springer
    Annals of hematology 60 (1990), S. 202-205 
    Details
    ISSN: 1432-0584
    Keywords: Anti-thoracic duct lymphocyte globulin ; Megakaryocytopoiesis ; Colony-forming unitmegakaryocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Anti-thoracic duct lymphocyte globulin (ALG) therapy is effective in patients with aplastic anemia. We examined the effect of ALG on human megakaryocyte progenitor cells (colony-forming unit-megakaryocyte, CFU-Meg) in vitro. Normal human bone marrow mononuclear cells (MNC) were cultured in plasma clots with varying concentrations of ALG or non-immunized horse IgG. After 12 days of culture, significant megakaryocyte colony formation was observed in cultures containing ALG but not in cultures containing non-immunized horse IgG. The peak stimulatory effect seemed to occur with 10–25µg/ml of ALG. When marrow MNC, depleted of adherent and T cells, were cultured in plasma clots with ALG, its stimulatory effect on megakaryocytopoiesis decreased markedly. Finally, it was demonstrated that ALG stimulated marrow MNC to produce a factor stimulatory for CFU-Meg. The in vitro megakaryocytopoietic stimulatory effect of ALG may be related to its clinical efficacy in some patients with aplastic anemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720277
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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