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  • 1
    Electronic Resource
    Electronic Resource
    The subcellular location of potassium flux pathways in frog skeletal muscle (1981)
    Springer
    Pflügers Archiv 390 (1981), S. 250-255 
    Details
    ISSN: 1432-2013
    Keywords: K-, Rb-uptake ; Ouabain ; Physostigmine ; Glycerol treatment ; Surface membrane ; Transverse tubules ; Frog muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of ouabain and physostigmine on42K and86Rb uptake in isolated frog sartorii with normal [Na] i (12–14 mmol·kg−1 wet weight) and low [Na] i (6 mmol·kg−1 wet weight) was compared. Both in normal-sodium and in low-sodium muscles application of 10−3 M physostigmine reduces potassium influx by about 70%. About one fourth of potassium-uptake in normal-sodium muscles is inhibited by ouabain (10−4M) and only a very slight fraction of potassium uptake is ouabain-sensitive in low-sodium muscle. The effects of ouabain and physostigmine on42K influx are additive. The greater parts of the Rb-fluxes are through the ouabainsensitive pathway. Glycerol treatment has no effect on ouabain-sensitive channels although it inhibits markedly the K-flux through the physostigmine-sensitive pathway. The results suggest that the Na−K-ATPase is located in the surface membrane while most of the physostigmine-sensitive K-exchange is within the tubules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00658270
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Total Synthesis of the Toxin Oosponol and of Structural Analogues and Investigation of Their Antibiotic Activities (1997)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1997 (1997), S. 773-777 
    Details
    ISSN: 0947-3440
    Keywords: Gloeophyllum abietinum ; Oosponol ; Isocoumarin ; Structure-activity relationships ; Antibiotics ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The toxic metabolite of the basidiomycete Gloeophyllum abietinum, oosponol (6b), and the structural analogues (Figure 1) were synthesised in order to investigate which partial structures of the molecules are responsible for their biological activities. Different organisms were employed to test the antibiotic activities of the analogues. From the results obtained with the synthetic analogues of oosponol (6b), it became evident that the toxicity of this fungal metabolite can be attributed to a vinylogous acid anhydride structure, which in nature is produced by dehydrogenation of the nontoxic precursor oospoglycol (7).
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199719970422
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  • 3
    Electronic Resource
    Electronic Resource
    Secondary Fungal Metabolites and Their Biological Activity, VIIIPart VII: J. Sonnenbichler, I. Zetl, D. Schwarz, Phytochemistry 1996, in press.. - Partial Synthesis of Oosponol, an Antifungal Isocoumarin (1997)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1997 (1997), S. 211-212 
    Details
    ISSN: 0947-3440
    Keywords: Isocoumarin ; Oosponol ; Pseudomonas fluorescens ; Antibiotics ; Secondary fungal metabolite ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The partial synthesis of oosponol (4), which shows significant antibiotic activity, has been accomplished by enzyme catalyzed reactions including regioselective acetylation of (-)-oospoglycol (1) followed by an oxidation step and hydrolysis by a lipase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199719970130
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    Paper (German National Licenses)
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