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  • Rheumatoid arthritis  (2)
  • Anticardiolipin Antibodies  (1)
  • Inflammatory Gut Lesions  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Generalized osteoporosis in non-steroid treated rheumatoid arthritis (1991)
    Springer
    Rheumatology international 11 (1991), S. 73-76 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Osteoporosis ; Dual photon absorptiometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the presence of reduced bone mineral density (BMD) and to assess determinants of bone loss in rheumatoid arthritis, 45 female patients suffering from non-steroid treated rheumatoid arthritis were submitted to dual photon absorptiometry of the lumbar spine and to laboratory tests for calcium metabolism. The rheumatoid arthritis patients were divided into two groups according to anatomic grade and functional class; no abnormalities in calcium metabolism were defected whereas BMD was significantly lower in the third and fourth grade and in the third and fourth class patients (P〈0.005 versus controls, versus grades I and II and versus classes 1 and 2). BMD was significantly correlated with age (P〈0.001) and years postmenopausal (P〈0.01), but not with duration of disease. By multiple inear regression we derived an equation predictive of BMD. Osteoporosis in rheumatoid arthritis is observed even in non-corticosteroid treated patients; articular lesions with subsequent reduction in physical activity appear to play an important role in axial bone loss in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291149
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serum zinc and copper in active rheumatoid arthritis: Correlation with interleukin 1β and tumour necrosis factor α (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 378-382 
    Details
    ISSN: 1434-9949
    Keywords: Copper ; Interleukin 1 ; Rheumatoid arthritis ; Tumour Necrosis Factor ; Zinc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum zinc and copper levels and serum interleukin 1β (IL1β) and tumour necrosis factor α (TNFα) levels were evaluated in 57 female patients with active rheumatoid arthritis (RA) to investigate a possible role of IL1β and TNFα on zinc and copper homeostasis in RA. Serum zinc levels were significantly lower and serum copper levels significantly higher in RA patients when compared with osteoarthritis or asymmetrical psoriatic oligoarthritis patients and with normal controls. No differences were observed in serum IgM rheumatoid factor positive and serum IgM rheumatoid factor negative patients as regards serum zinc and copper concentration. In RA patients the erythrocyte sedimentation rate and acute-phase proteins correlated negatively with serum zinc and positively with serum copper. IL1β and TNFα were found to correlate negatively with zinc and positively with copper in RA patients. Lower levels of zinc may be due to an accumulation of zinc-containing proteins in the liver and in the inflamed joints in RA. Elevated serum copper levels seem to be linked to the increased synthesis of ceruloplasmin by the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01450895
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Clinically silent inflammatory gut lesions in undifferentiated spondyloarthropathies (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 565-570 
    Details
    ISSN: 1434-9949
    Keywords: Undifferentiated Spondyloarthropathies ; Colonoscopy ; Inflammatory Gut Lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gastrointestinal inflammation or infection can be associated with various forms of arthritis, such as, acute reactive arthritis triggered by enteritis due to gram-negative bacteria or ankylosing spondylitis and peripheral arthritis in relation to Crohn's disease and ulcerative colitis. Using colonoscopy, we have found a high prevalence of clinically silent inflammatory lesions in 38 patients (24 males and 14 females) affected by undifferentiated spondyloarthropathies (SpA). Microscopic inflammatory lesions were present in all the patients. Three patterns of nonspecific chronic inflammatory alterations were observed. No difference was noted between patients taking or not taking nonsteroidal anti-inflammatory drugs. Direct immunofluorescence demonstrated the presence of IgG, IgA, IgM, C3, C4 and fibrinogen in 75% of the specimens examined. The finding of chronic inflammatory gut lesions hypothesizes that a local activation of the immune system depending on the persistence of intestinal microbial antigens or toxins, due to impaired elimination or increased exposition, may have a part in the pathogenesis of SpA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242995
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Lack of correlation between anticardiolipin antibodies and peripheral autonomic nerve involvement in systemic lupus erythematosus (1992)
    Springer
    Clinical rheumatology 11 (1992), S. 231-234 
    Details
    ISSN: 1434-9949
    Keywords: Systemic Lupus Erythematosus ; Anticardiolipin Antibodies ; Peripheral Autonomic Neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of anticardiolipin antibodies has recently been related to a clinical complex in which both central and peripheral neurologic damage is included. A series of 27 female patients affected by systemic lupus erythematosus (SLE) was tested for the presence of peripheral autonomic neuropathy and serum anticardiolipin antibody (ACA) levels were determined in each patient by ELISA. Peripheral autonomic impairment was detected in 40.7% of SLE patients and a large number (77.7%) of patients had elevated levels of ACA. No relationship was found between presence of ACA (both for IgG and IgM classes) and the autonomic neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207963
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    Paper (German National Licenses)
    Fulltext
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