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Effects on fracture healing of an antagonist of the vitamin K cycle (1984)

Dodds, R. A. ; Catterall, A. ; Bitensky, Lucille ; [et al.]

Springer

Calcified tissue international 36 (1984), S. 233-238

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ISSN: 1432-0827

Keywords: Vitamin K cycle ; Anticoagulant therapy ; Experimental fracture healing ; Quantitative cytochemistry

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Summary The anticoagulant, dicumarol, inhibits the vitamin K cycle by blocking the conversion of the vitamin K epoxide. The effects of dicumarol on ossification have been tested by feeding it to rats in which a closed fracture of the metatarsals had been induced; the effects were studied up to 12 days postfracture. At 12 days, treatment with dicumarol caused a highly significant decrease in the amount of bone produced, without affecting the total size of the callus. Quantitative cytochemistry of unfixed, undemineralized sections showed that dicumarol also markedly affected the periosteal activities of glucose 6-phosphate dehydrogenase and of alkaline phosphatase in the first 2 mm from the fracture measured at 3 and 5 days postfracture when normally, new bone is first formed. In contrast, dicumarol had little effect on these activities in the fully formed callus.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02405322

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Electronic Resource

Skerry, T. M. ; Bitensky, L. ; Chayen, J. ; [et al.]

Hoboken, NJ [u.a.] : Wiley-Blackwell

Journal of Orthopaedic Research 6 (1988), S. 547-551

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ISSN: 0736-0266

Keywords: Bone tissue ; Proteoglycan ; Bone strain ; Dynamic loading ; Life and Medical Sciences

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine

Notes: The load-carrying capacity of the skeleton is achieved and maintained as the result of a continued functional stimulus to the cell populations responsible for bone remodeling. Although some bone cells have been assumed to be influenced by the load-induced changes in strain throughout the matrix, no evidence is available to indicate which cells are susceptible to such strain change or how such transient events provide a sustained influence on cell behaviour. In the present study, we showed that a short period of dynamic loading in vivo affects the orientation of proteoglycan within bone tissue. This reorientation declines only slowly, thus providing a persistent record of the tissue's recent strain history. Such a record has the ability not only to “capture” strain transients but also to “update” and “average” them. In this way, the bone cells could be presented with a sustained and coherent stimulus directly related to dynamic strain transients. These transients are the tissue's principal function variable.

Additional Material: 3 Ill.