ISSN:
1432-2072
Keywords:
Thyrotropin-releasing hormone
;
Antidepressant agents
;
Brain stem
;
Hypothalamus
;
Multiple unit activity
;
REM sleep
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The EEG and MUA (multiple unit activity) of mesencephalic reticular formation (MRF), area hypothalami posterior (PH), and area hypothalami anterior (AH) were studied in chronically implanted freely moving cats. The effects of thyrotropin-releasing hormone (TRH) and some antidepressant agents were tested on neuronal activity. Desipramine and imipramine resulted in a dose-dependent decline of MUA of all structures with the most significant decrease of activity in PH. A single injection of TRH resulted in slight or moderate gross behavioral changes and vegetative excitation lasting for 30–50 min with variable MUA levels. In the course of repetitive TRH treatment on consecutive days the gross behavioral changes and the vegetative symptoms failed to develop by the 3rd or 4th day. By that time the MUA changes of PH and MRF showed similar characteristics in response to TRH administration which was observed following the injection of desipramine and imipramine. The drugs, except for TRH, induced a suppression of paradoxical sleep cycles.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427290
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