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  • 1
    Electronic Resource
    Electronic Resource
    Das zentrale dopaminerge System und die Depression (1997)
    Springer
    Der Nervenarzt 68 (1997), S. 545-555 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Dopamin ; Depression ; Antidepressiva ; Neurobiologie ; Neuroimaging ; Key words Dopamine ; Depression ; Antidepressants ; Neurobiology ; Neuroimaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This review presents data supporting the involvement of the dopaminergic system in depressive illness. Neuroanatomical research, animal research and clinical studies have shown that a dysfunction of the mesolimbic dopaminergic system could be associated with depressive symptoms. Furthermore, the chronic administration of antidepressants in animals provokes a sensitisation and enhanced expression of dopaminergic receptors. Although the dopaminergic system has received little attention in biological research on depression in the last decades, current research on the dopaminergic system is about to change this situation.
    Notes: Zusammenfassung In dieser Übersichtsarbeit werden ältere und neuere Ergebnisse der Erforschung des dopaminergen Systems in der Depression vorgestellt. Sowohl neuroanatomische und tierexperimentelle als auch klinische Studien geben Hinweise darauf, daß depressive Syndrome mit einer Dysfunktionalität des mesolimbischen dopaminergen Systems verbunden sein können. Darüber hinaus führt die chronische Gabe von Antidepressiva zu einer Sensitivierung und einer gesteigerten Expression dopaminerger Rezeptoren. Dem über lange Zeit wenig beachteten dopaminergen System scheint in der Pathogenese der Depression eine größere Bedeutung zuzukommen als bislang angenommen wurde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050159
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  • 2
    Electronic Resource
    Electronic Resource
    Neurobiological similarities in antidepressant sleep deprivation and psychostimulant use: a psychostimulant theory of antidepressant sleep deprivation (1998)
    Springer
    Psychopharmacology 140 (1998), S. 1-10 
    Details
    ISSN: 1432-2072
    Keywords: Key words Depression ; Sleep deprivation ; Psychostimulant ; Dopamine ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper attempts to summarize the evidence for the hypothesis that psychostimulant-like neurotransmitter processes within certain regions of the limbic system induce the positive effects of antidepressant sleep deprivation (SD). Preclinical and human studies indicate similar neurobiological effects of psychostimulants such as amphetamines, cocaine and SD. In clinical use, SD and psychostimulants have similar characteristics and behavioral effects. Furthermore, acute psychostimulant challenge decreases limbic metabolism in imaging studies, and SD decreases elevated limbic metabolism in SD responders, indicating that psychostimulant-like neurotransmitter release could decrease limbic metabolism in SD responders. Most antidepressant pharmacotherapies change the reactivity of the dopamine system, and a decrease of presynaptic dopamine or postsynaptic availability can induce depression. Sleep is accompanied by a reduction of catecholamine release and those processes which are increased by psychostimulants. It is concluded that a proposed regional postsynaptic deficit in catecholaminergic neurotransmission can be overcome either acutely by enhanced release during SD or psychostimulant use, or chronically by changes in receptor sensitivity or gene expression due to antidepressant therapies. A postsynaptic deficit in these areas becomes evident if presynaptic release is reduced in conditions such as sleep. Therefore, sleep is depressiogenic for predisposed individuals and the reduction of sleep avoids understimulation of subsensitive postsynaptic processes, which are enhanced by psychostimulants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050732
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Dopamine and depression — Striatal dopamine D2 receptor SPECT before and after antidepressant therapy (1996)
    Springer
    Psychopharmacology 126 (1996), S. 91-94 
    Details
    ISSN: 1432-2072
    Keywords: Depression ; Dopamine ; Dopamine receptors ; Brain imaging ; SPECT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ten unmedicated and ten medicated patients with major depression and ten controls were investigated with IBZM-SPECT. The ten unmedicated patients were reinvestigated after treatment with tricyclic antidepressants. Dopamine D2 receptor occupancy was not different between patients and controls, or medicated and unmedicated patients. IBZM binding was increased in four patients with psychomotor retardation. Antidepressant therapy led to a decrease in IBZM binding in the five improved patients. Dopamine D2 receptor binding remained unchanged in nonresponders. It is concluded that striatal dopamine D2 receptor binding is not changed in depression or by tricyclic antidepressants; however, it is affected by psychomotor activity. The changes observed might be the result of increased tonic dopamine release in the basal ganglia, but several other explanations exist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246416
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    Paper (German National Licenses)
    Fulltext
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