ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Antiepileptic drugs
;
Optimised separation
;
Serum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A fast and easy, iscratic high-performance liquid chromatographic method for the simultaneous determination of primidone, phenobarbital, phenytoin, carbamazepine and thiobutabarbital from serum samples has been developed. The optimal eluent composition is 36% acetonitrile, 24% methanol and 40% phosphate buffer. Using a programmable wavelength detector very low (sub-therapeutic) levels of the drugs can be measured.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02262474
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