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  • 1
    ISSN: 1476-5535
    Keywords: Antifungal ; Sch 40873 ; Candida albicans ; Mycelial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Sch 40873, a novel antifungal compound isolated from the fermentation broth of anActinomadura spp. was discovered in an assay designed to detect compounds with preferential activity against the invasive mycelial form ofCandida albicans. The geometric mean MIC of Sch 40873 against sevenCandida spp. in Sabouraud dextrose broth (yeast phase) was ≥58 μg/ml and in Eagles minimum essential medium (mycelial phase) was 〈0.03 μg/ml. Sch 40873 demonstrated slight in vivo topical activity in a hamster vaginal model.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 5 (1985), S. 225-244 
    ISSN: 0271-2091
    Keywords: Convection-Diffusion ; Differencing Schemes ; Discretization Errors ; False Diffusion ; Upwind Scheme ; Higher Order Schemes ; Accuracy ; Stability ; Computational Cost ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A comparative study of seven discretization schemes for the equations describing convection-diffusion transport phenomena is presented. The (differencing) schemes considered are the conventional central- and upwind-difference schemes, together with the Leonard,1 Leonard upwind1 and Leonard super upwind difference1 schemes. Also tested are the so called locally exact difference scheme2 and the quadratic-upstream difference scheme.3,4 In multidimensional problems errors arise from ‘false-diffusion’ and function approximations. It is asserted that false diffusion is essentially a multidimensional source of error. No mesh constraints are associated with errors in function approximation and discretization. Hence errors associated with discretization only may be investigated via one-dimensional problems. Thus, although the above schemes have been tested for one- and two-dimensional flows with sources, only the former are presented here. For 1D flows, the Leonard super upwind difference scheme and the locally exact scheme are shown to be far superior in accuracy to the others at all Peclet numbers and for most source distributions, for the test cases considered. Furthermore, the latter is shown to be considerably cheaper in computational terms than the former. The stability of the schemes and their CPU time requirements are also discussed.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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