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  • 1
    Electronic Resource
    Electronic Resource
    Diffusion of a lymph-carried antigen in the fiber network of the lymph node of the rat (1986)
    Springer
    Cell & tissue research 245 (1986), S. 481-486 
    Details
    ISSN: 1432-0878
    Keywords: Antigen distribution in lymph node ; Reticular-fiber network of lymph node
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A lymph-carried antigen is retained preferentially in those areas of the subcapsular sinus of a lymph node overlying the extrafollicular zone of the peripheral cortex. There, it becomes associated with the reticular fibers crossing these particular sinus areas. We wondered whether the antigen thereafter diffuses along the extensions of these fibers which form a peculiar network in the “cortical pathways of migration of circulating lymphocytes” (CPMCL), leading to the different cell populations effecting the immune responses. Fluorescein isothiocyanate (FITC)-conjugated antigens were injected locally into rats sacrificed 0.5–24 h later. The antigens diffused along the fibers of the CPMCL. It is proposed that this diffusion constitutes one mechanism of stimulation of recruited circulating lymphocytes and of orientation of their migration towards the proper effector-cell population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218547
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Atrophy of compartments of rat lymph nodes related to an entry of lethally altered lymphocytes (1990)
    Springer
    Cell & tissue research 262 (1990), S. 263-271 
    Details
    ISSN: 1432-0878
    Keywords: Alteration of lymphocytes ; Mast cells ; Weakening of immune system ; Aging ; Atrophy ; Lymph node ; Athymic animal ; Rat (Sprague-Dawley)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This paper reports the occurrence of an accumulation of lethally altered lymphocytes in the subcapsular sinus of a compartment or compartments of some lymph nodes, an unusual feature best developed in nodes of the mesenteric site in aging athymic animals. Many of these cells are rod-like. In other compartments, similar lymphocytes occurred at various depths in the nodal parenchyma. This was accompanied by the disappearance of a compartment's populations of normal lymphoid cells. The observations reveal that lymphocytes, altered in a tissue, may reach the subcapsular sinus of the draining node compartment and migrate into its parenchyma which then undergoes atrophy. The likely involvement of mast cells is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309881
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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