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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 245 (1986), S. 481-486 
    ISSN: 1432-0878
    Keywords: Antigen distribution in lymph node ; Reticular-fiber network of lymph node
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A lymph-carried antigen is retained preferentially in those areas of the subcapsular sinus of a lymph node overlying the extrafollicular zone of the peripheral cortex. There, it becomes associated with the reticular fibers crossing these particular sinus areas. We wondered whether the antigen thereafter diffuses along the extensions of these fibers which form a peculiar network in the “cortical pathways of migration of circulating lymphocytes” (CPMCL), leading to the different cell populations effecting the immune responses. Fluorescein isothiocyanate (FITC)-conjugated antigens were injected locally into rats sacrificed 0.5–24 h later. The antigens diffused along the fibers of the CPMCL. It is proposed that this diffusion constitutes one mechanism of stimulation of recruited circulating lymphocytes and of orientation of their migration towards the proper effector-cell population.
    Type of Medium: Electronic Resource
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