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  • 1
    ISSN: 1432-1440
    Keywords: Cyclosporin A ; Steroid ; Cadaveric renal transplantation ; Nephrotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The actual survival rate of 25 primary cadaveric kidney grafts in recipients treated initially with cyclosporin A (CyA) alone was 84%. The survival rate in 37 patients under conventional immunosuppression was 76%. The mean number of dialyses required in the first 4 weeks after transplantation was 1.2 per patient in both groups. At 15–28 months posttransplant, mean serum creatinine levels have remained stable at 175 µmol/l in the CyA group. The mean daily dose of steroids (including methylprednisolone i.v.) in the first two months was 2.07 mg/kg/d in patients under conventional immunosuppression and 0.76 mg/kg/d in the patients receiving CyA (p〈0.001). The combination of CyA with low-dose steroids enabled the dose of CyA to be rapidly tapered off in once-weekly steps. CyA levels were monitored by determination of whole blood trough concentrations (target level: 300–800 ng/ml). At 60 days posttransplant the average dose of CyA was 6.0±0.5 mg/kg/d compared with an average daily dose of 11.4±0.9 as recommended for CyA alone in the protocol for the European multicentre study. This more rapid reduction in the CyA dose reduced nephrotoxicity (serum creatinine levels 174±14 as compared with 289±31 µmol/l) (p〈0.05) and almost halved the number of methylprednisolone pulses given up to the end of the second month. We conclude from these results (1) that previously the dosage of CyA administered at this centre was probably too high, and (2) early adjustment of dose levels on the basis of blood concentrations and with low-dose prednisone cover appears to be safe and effective, but requires further verification.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 516-516 
    ISSN: 1435-2451
    Keywords: Kidney transplantation ; Transfusion ; Antibodies ; Nierentransplantation ; Bluttransfusion ; Antikörper
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vom 1.1.1977–31.12.1979 wurden 72 Nierentransplantationen durchgeführt. Alle Empfänger hatten nach einem Schema Bluttransfusionen erhalten. Nachuntersucht wurde das Auftreten lymphocytotoxischer Antikörper, die Wartezeit und die Transplantatfunktion. Bei 65 % der Patienten traten nie Antikörper auf. 72% der Transplantate überlebten 1 Jahr; 69% 2 Jahre. Die durch unser Transfusionsprogramm verbesserten Resultate kamen nicht durch eine transfusionsbedingte Selektion zustande, da die wenigen Reaktoren zwar länger warteten, alle aber doch noch ein Transplantat bekamen.
    Notes: Summary From January 1977 through December 1979, 72 kidney transplantations were made. All recipients received transfusions according to a special plan. The development of lymphocytotoxic antibodies, the waiting time, and the function of the transplant were checked. Of the total patients, 65% never developed antibodies. After one year, the survival rate of the transplants was 72%; after two years, survival was 69%. The better results after our transfusion program were not achieved by selection. A few high responders had to wait longer, but all of them finally received a transplant.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 61-68 
    ISSN: 1434-4726
    Keywords: Facial injuries ; Skull base injuries ; Miniplate osteosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Miniplate osteosynthesis is an osteoplastic procedure that achieves secure stabilization of the midface, even following extensive fractures of the midface and the floor of the anterior cranial fossa. This procedure can be considered a satisfactory operative treatment in terms of cosmetic and functional results. Correlative osteology is discussed and clinical experiences are reviewed.
    Type of Medium: Electronic Resource
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