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  • Antimetabolite therapy  (1)
  • Karst areas  (1)
  • Key words Herpes simplex virus  (1)
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  • 1
    ISSN: 1432-1998
    Keywords: Polyarteritis nodosa ; Angiography ; Hypertension ; Antimetabolite therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Angiographic illustration of aneurysmal involvement of renal, hepatic, and splenic arteries in a 10-year-old boy, led to correct diagnosis of polyarteritis nodosa. A follow-up study one year after cyclophosphamide and prednisone therapy showed near complete resolution of the arterial lesions and a marked improvement of renal blood flow.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Environmental geology 22 (1993), S. 314-320 
    ISSN: 1432-0495
    Keywords: Karst areas ; Sinkhole development ; Groundwater quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract During a 3000-gpm pump test on a groundwater supply well in Augusta County, Virginia, residential properties were impacted. The impacts included lowered farm pond water levels, development of a sinkhole, and water level decrease in residential wells. A study was performed to assess whether a lower design yield was possible with minimal impacts on adjacent property. This study included a 48-h 1500-gpm pump test that evaluated impacts due to: (1) sinkhole development and potential damage to homes, (2) loss of water in residential wells, and (3) water-quality degradation. Spring flows, residential well levels, survey monuments, and water quality were monitored. Groundwater and surface water testing included inorganic water-quality parameters and microbiological parameters. The latter included particulate analyses,Giardia cysts, and coliforms, which were used to evaluate the connection between groundwater and local surface waterbodies. Although results of the study indicated a low potential for structural damage due to future sinkhole activity, it showed that the water quality of some residential wells might be degraded. Because particulate analyses confirmed that groundwater into the supply well is under the direct influence of surface water, it was recommended that certain residents be placed on an alternate water supply prior to production pumping and that filtration be provided for the well in accordance with the Surface Water Treatment Rule. A mitigation plan was implemented. This plan included crack surveys, a long-term settlement station monitoring program, and limitation of the groundwater withdrawal rate to 1.0 million gallons per day (mgd) and maximum production rate to 1500 gpm.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1831
    Keywords: Key words Herpes simplex virus ; Vaccine ; Intracellular ; Subunit ; Clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A randomised, placebo-controlled, multi-centre trial of intracellular subunit herpes simplex virus (HSV) type 1 vaccine NFU.Ac.HSV-1(S–)MRC (Skinner vaccine) was conducted at three medical centres in the United States. Subjects with documented herpes genitalis of at least 1-year duration and a history of six or more genital HSV recurrences in the 12 months prior to study entry were randomised to receive vaccine or placebo at 0, 1 and 2 months. Vaccination induced significant neutralising, enzyme-linked immunosorbent assay and lymphocyte transformation response to HSV-1 antigen. The frequency of recurrences was reduced in the vaccinated female patients at both 3 and 6 months following vaccination with an overall reduction in patients of both sexes which did not reach statistical significance. Recurrence severity was reduced as measured by decreased number of lesions and associated symptoms per recurrence (P = 0.04). The data suggest that clinical manifestations of latent HSV genital infection may be modified by therapeutic immunisation.
    Type of Medium: Electronic Resource
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