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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis of some substituted triazolo[4,3-b][1,2,4]triazines as potential anticancer agents (1988)
    Springer
    Monatshefte für Chemie 119 (1988), S. 591-596 
    Details
    ISSN: 1434-4475
    Keywords: Antineoplastic ; Potential-azapurine analogues ; Triazolo[4,3-b][1,2,4]triazine ; synthesis and biological evaluation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wird die Synthese einiger 3-substituierter Amino-6,7-diphenyl-1,2,4-triazolo[4,3-b][1,2,4]-triazine (15) mittels Cyclodesulfurisierung der entsprechenden N-(5,6-Diphenyl-1,2,4-triazin-3-yl)-N′-[subst.thio(carbamoyl)]-hydrazine (3) unter Verwendung von Dicyclohexylcarbodiimid (DDQ) beschrieben. Versuche zur Herstellung von 3-substituierten Amino-7-hydroxy-6-methyl-triazolo[4,3-b][1,2,4]-triazinen schlugen fehl.
    Notes: Abstract The synthesis of some 3-substituted amino-6,7-diphenyl-1,2,4-triazolo[4,3-b][1,2,4]triazines (15) by cyclodesulfurisation of the corresponding N-(5,6-diphenyl-1,2,4-triazin-3-yl)-N′-[substituted thio (carbamoyl)]hydrazines (3) using dicyclohexylcarbodiimid (DCC) and mercuric chloride is described. Moreover, trials to prepare 3-substituted amino-7-hydroxy-6-methyl-1,2,4-triazolo[4,3-b][1,2,4]triazines were not successful.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00809211
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  • 2
    Electronic Resource
    Electronic Resource
    Pattern of electroencephalographic abnormalities in children with hydrocephalus A study of 68 patients (1998)
    Springer
    Child's nervous system 14 (1998), S. 124-126 
    Details
    ISSN: 1433-0350
    Keywords: Key words Hydrocephalus ; EEG ; Children ; Saudi Arabia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pattern of electroencephalographic (EEG) abnormalities was studied in 68 patients (41 male, 27 female, age range 1 month to 17 years) with hydrocephalus. They all had standardized EEG recordings, which were read by the same electroencephalographer. In 48 children the EEG was performed after ventriculo-peritoneal shunting. The EEG abnormalities in the shunted group included slow waves in 26 patients [focal 2 (4.2%), generalized asynchronous 22 (45.8%), generalized synchronous 2 (4.2%)]; amplitude abnormalities in 2 (focal 1, generalized 1); epileptiform activity in 26 [partial 11 (22.9%), generalized 15 (31.3%)] and hypsarrhythmia in 4 (8.3%). Only 4 (8.3%) traces were normal, giving an overall percentage abnormality of 92%. In the unshunted group generalized asynchronous slow waves were found in 12 patients (60%), generalized amplitude abnormality in 1, focal epileptiform activity in 3 (15%), and generalized epileptiform activity in 6 (30%); 2 tracings in this group were normal, giving an overall percentage abnormality of 90%. Hydrocephalus in children, regardless of the cause, may be associated with generalized or focal EEG abnormalities. This may reflect the heterogeneity of the neural generator in the underlying disease process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050193
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical pattern of newly-diagnosed seizures in Saudi Arabia: a prospective study of 263 children (1999)
    Springer
    Child's nervous system 15 (1999), S. 468-471 
    Details
    ISSN: 1433-0350
    Keywords: Key words Seizures ; Epilepsy ; Children ; EEG ; Computed tomography (CT) ; Saudi Arabia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The clinical patterns, including history, examination, and electroencephalographic (EEG) and computed tomography (CT) findings were examined prospectively in 263 children (153 boys, 110 girls) with newly diagnosed recurrent seizures. The overall mean age was 4.2 years, with a range of 0.05–13 years. The age of onset was within the first year of life in 128 (48.7%) of the patients. Hypoxic-ischemic encephalopathy (14.8%), febrile seizures (9.1%) and developmental delay (4.6%) were the predominant signs in this age group. Consanguinity of the parents was present in 29.7% cases. The main EEG abnormalities were epileptiform activity, which was generalized in 133 (50.6%) and focal in 80 (30.4%). Other abnormalities included slow wave activity in 41 (15.6%) and hypsarrhythmia in 3 (1.1%). The main seizure types were generalized in 60.4% and partial in 32.7%. The types of epileptic syndromes included localization-related (28.1%), generalized (23.2%), undetermined (37.4%) and (special) syndromes 11.4%. The cranial CT findings were normal in 60.5%, and the predominant abnormality was cerebral atrophy in 25.3%. The pattern of seizure types and the peak presentation in early childhood are comparable to those in western reports.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050441
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  • 4
    Electronic Resource
    Electronic Resource
    Does Gγ/Aγ ratio and Hb F level influence the severity of sickle cell anaemia (1993)
    Springer
    Molecular and cellular biochemistry 124 (1993), S. 17-22 
    Details
    ISSN: 1573-4919
    Keywords: sickle cell anaemia ; Hb F ; Saudi Arabia ; globin genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Sickle cell anaemia (SCA) exhibits significant variations in clinical presentation in different populations for which several genetic factors including SCA-associated α-and β-thalassaemias, G-6-PD deficiency and elevated Hb F level have been implicated as possible ameliorating factors. Saudi Arabia is unique in that mild and severe forms of the disease occur at a high frequency. We investigated the Gγ/Aγ ratio and Hb F level and correlated these values with the severity of SCA. The results showed that Hb F level varies significantly in both groups of patients with no evident correlation with the mild clinical manifestations. However, Gγ/Aγ ratio correlated significantly with the disease severity where a high ratio was observed in patients with the mild and a low ratio in patients with the severe disease. The results are evaluated and discussed in the light of correlation studies and regression analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01096377
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    Paper (German National Licenses)
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