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  • Clonidine-displacing substance  (2)
  • Lateral geniculate nucleus  (2)
  • Antireflux surgery  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Agmatine recognizes α2-adrenoceptor binding sites but neither activates nor inhibits α2-adrenoceptors (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1994), S. 10-16 
    Details
    ISSN: 1432-1912
    Keywords: Key words Agmatine ; α2-Adrenoceptor binding sites ; α2-Adrenoceptors ; Clonidine-displacing substance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been suggested that agmatine (decarboxylated arginine) is an endogenous clonidine-displacing substance (CDS) which recognizes α2-adrenoceptor and non-adrenoceptor, imidazoline binding sites. We have examined the effect of agmatine at α2-adrenoceptor binding sites and pre- and postjunctional α2-adrenoceptors. Agmatine produced a concentration-dependent inhibition of 1 nmol/l 3H-clonidine binding to both rat (pKi–5.10±0.05) and bovine (pKi–4.77±0.38) cerebral cortex membranes. However, agmatine (0.1–100 μM) failed to activate pre-junctional α2-adrenoceptors regulating transmitter release in the guinea-pig isolated ileum and rat isolated vas deferens, nor did it activate postjunctional α2-adrenoceptors of the porcine isolated palmar lateral vein which mediate contraction or inhibition of forskolin-stimulated cyclic AMP formation. High concentrations of agmatine (10–30-fold the pKi at α2-adrenoceptor binding sites) failed to influence α2-adrenoceptor activation by either clonidine or UK-14304 (5-bromo-6-[2-imidazolin-2-ylamino]-quinoxaline bitartrate) in any of the peripheral preparations examined. Moreover, even in a preparation where an interaction with α2-adrenoceptor binding sites on cell membranes can be demonstrated, the rat cerebral cortex, agmatine failed to inhibit forskolin-stimulated cyclic AMP in the intact tissue or affect the inhibition produced by the selective α2-adrenoceptor agonist UK-14304. Agmatine was also devoid of agonist activity in two preparations, the rat isolated thoracic aorta and the rat isolated gastric fundus, in which CDS has been reported to produce non-adrenoceptor effects. Thus, we have confirmed that agmatine recognizes α2-adrenoceptor binding sites and, therefore, is a CDS. However, since agmatine is devoid of pharmacological activity at either peripheral or central α2-adrenoceptors it can not account for earlier reports suggesting that brain-derived CDS can activate α2-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169058
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Agmatine recognizes α2-adrenoceptor binding sites but neither activates nor inhibits α2-adrenoceptors (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 10-16 
    Details
    ISSN: 1432-1912
    Keywords: Agmatine ; α2-Adrenoceptor binding sites ; α2-Adrenoceptors ; Clonidine-displacing substance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been suggested that agmatine (decarboxylated arginine) is an endogenous clonidine-displacing substance (CDS) which recognizes α2-adrenoceptor and non-adrenoceptor, imidazoline binding sites. We have examined the effect of agmatine at α2-adrenoceptor binding sites and pre- and postjunctional α2-adrenoceptors. Agmatine produced a concentration-dependent inhibition of 1 nmol/l 3H-clonidine binding to both rat (pKi–5.10+-0.05) and bovine (pKi–4.77+-0.38) cerebral cortex membranes. However, agmatine (0.1–100 μM) failed to activate pre-junctional α2-adrenoceptors regulating transmitter release in the guinea-pig isolated ileum and rat isolated vas deferens, nor did it activate post-junctional α2-adrenoceptors of the porcine isolated palmar lateral vein which mediate contraction or inhibition of forskolin-stimulated cyclic AMP formation. High concentrations of agmatine (10–30-fold the pKi at α2-adrenoceptor binding sites) failed to influence α2-adrenoceptor activation by either clonidine or UK-14304 (5-bromo-6-[2-imidazolin-2-ylamino]-quinoxaline bitartrate) in any of the peripheral preparations examined. Moreover, even in a preparation where an interaction with α2-adrenoceptor binding sites on cell membranes can be demonstrated, the rat cerebral cortex, agmatine failed to inhibit forskolin-stimulated cyclic AMP in the intact tissue or affect the inhibition produced by the selective α2-adrenoceptor agonist UK-14304. Agmatine was also devoid of agonist activity in two preparations, the rat isolated thoracic aorta and the rat isolated gastric fundus, in which CDS has been reported to produce non-adrenoceptor effects. Thus, we have confirmed that agmatine recognizes α2-adrenoceptor binding sites and, therefore, is a CDS. However, since agmatine is devoid of pharmacological activity at either peripheral or central α2-adrenoceptors it can not account for earlier reports suggesting that brain-derived CDS can activate α2-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169058
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Endoskopische intraluminale Valvuloplastik – Eine Therapie der Zukunft für die gastrooesophageale Refluxkrankheit (1998)
    Springer
    Der Chirurg 69 (1998), S. 158-162 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Gastroesophageal reflux disease ; Antireflux surgery ; Minimally invasive surgery ; Endoscopic intervention. ; Schlüsselwörter: Gastrooesophageale Refluxkrankheit ; Antirefluxchirurgie ; minimal-invasive Chirurgie ; endoskopische Intervention.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Eine neue endoskopische, intraluminale Valvuloplastik wird beschrieben. Es handelt sich hierbei um einen einfachen, ambulant durchführbaren Antirefluxeingriff, der bei Patienten mit frühen Stadien der gastrooesophagealen Refluxkrankheit eine Alternative zur lebenslangen medikamentösen Dauertherapie bieten könnte. Die Technik des Eingriffs, die Effektivität und erste Langzeitergebnisse im Tierversuch an Pavianen werden dargestellt.
    Notes: Summary. A new endoscopic intraluminal valvuloplasty is described. The procedure provides a simple, easy outpatient approach for antireflux surgery and is applicable to patients with early gastroesophageal reflux disease as an alternative to chronic life-long medical therapy. The feasibility, durability and efficacy of the procedure in baboons are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050390
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Cell properties in the medial interlaminar nucleus of the cat's lateral geniculate complex in relation to the transient/sustained classification (1975)
    Springer
    Experimental brain research 22 (1975), S. 327-329 
    Details
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Medial interlaminar nucleus ; Receptive field properties ; Transient/sustained classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234773
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Responses of cells in the dorsal lateral geniculate complex of the cat to textured visual stimuli (1976)
    Springer
    Experimental brain research 25 (1976), S. 323-326 
    Details
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Medial interlaminar nucleus ; Receptive field ; ‘Visual noise’
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234022
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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