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  • 1
    Electronic Resource
    Electronic Resource
    Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice (2000)
    Springer
    Cancer immunology immunotherapy 49 (2000), S. 157-164 
    Details
    ISSN: 1432-0851
    Keywords: Key words Lactobacillus plantarum ; IL-12 ; Antitumor immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We have previously reported that heat-killed Lactobacillus plantarum L-137 is a potent inducer of interleukin-12 (IL-12) in vivo as well as in vitro in mice. In order to develop effective usage of L. plantarum L-137 for tumor immunotherapy, we examined its antitumor effect against DBA/2 mice inoculated with syngenic P388D1 tumor cells in different treatment schedules. Daily injection of L. plantarum L-137 from the day of tumor inoculation induced a steep increase in plasma IL-12 only after the first injection but not after subsequent injections, and had no effect on tumor growth and survival time. In contrast, daily injection of L. plantarum L-137 from the 7th day after tumor inoculation exerted a marked antitumor effect but such an effect was not evident in mice treated with L. plantarum L-137 twice a week from the 7th day. IL-12 production was considerably impaired at the first injection but steeply increased after the third injection in the mice injected daily with L. plantarum L-137 from the 7th day. Our results suggest that daily administration of L. plantarum L-137 is required to exert an antitumor effect at the late stages of tumor development when IL-12 production is considerably impaired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050615
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  • 2
    Electronic Resource
    Electronic Resource
    Frequent Detection of Hepatitis B Virus X-Gene DNA in Hepatocellular Carcinoma and Adjacent Liver Tissue in Hepatitis B Surface Antigen-Negative Patients (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 2264-2269 
    Details
    ISSN: 1573-2568
    Keywords: HEPATOCELLULAR CARCINOMA ; HEPATITIS B VIRUS ; POLYMERASE CHAIN REACTION ; TRANSACTIVATOR ; HBSAG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatitis B virus is associated with humanhepatocellular carcinoma. We performed polymerase chainreaction for the X, C, S, and preS2/S regions of theviral genome in 23 hepatitis B surface antigen-negative hepatocellular carcinomas and adjacent liver.Hepatitis B viral genomes were detected in 17 of 23tumors and adjacent tissues (73.9%). Among recognizedtransactivators, the X gene was present in 16 (69.6%) cases of hepatocellular carcinoma, but preS2/Swas detected in only 7 (30.4%). Hepatitis B virus C andS regions were detected in 3 (13.0%) and 9 (39.1%)hepatocellular carcinomas, respectively. Serologic study revealed antibodies to hepatitis Bsurface antigen, hepatitis B core antigen, and hepatitisB e antigen in 14 patients; among these, X-gene DNA wasdetected in 12 of 14 tumors (85.7%). The X gene was also detected in 4 of 9 tumors ofseronegative patients. The X gene, present in manyhepatocellular carcinomas, may promote hepatocellularcarcinoma in hepatitis B surface antigen-negativepatients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018814700915
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    Paper (German National Licenses)
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