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  • 1
    Electronic Resource
    Electronic Resource
    Comparative behavioral effects of clorgyline and pargyline in man: A preliminary evaluation (1979)
    Springer
    Psychopharmacology 62 (1979), S. 123-128 
    Details
    ISSN: 1432-2072
    Keywords: Monoamine oxidase inhibitors ; Depression ; Anxiety ; Clorgyline ; Pargyline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antidepressant and other behavioral effects of clorgyline, a preferential inhibitor of monoamine oxidase (MAO) type A, were compared with those of pargyline, a preferential inhibitor of MAO type B, in 16 depressed patients. In a subgroup of more severely depressed patients, clorgyline treatment for 4 weeks resulted in significant improvement on both observer-rated and self-rated scales, while minimal changes occurred during pargyline treatment. Similarly, in a crossover study that included 8 patients examined with multiple scales, clorgyline had generally greater antidepressant and antianxiety effects than did pargyline, although pargyline had some activating effects and also tended to produce more side effects. MAO type A inhibition may be more important than MAO type B inhibition for antidepressant efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427124
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers (1989)
    Springer
    Psychopharmacology 98 (1989), S. 275-282 
    Details
    ISSN: 1432-2072
    Keywords: Anxiety ; Serotonin ; Cortisol ; Prolactin ; Temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The serotonin agonist m-chlorophenylpiperazine (m-CPP) had greater anxiogenic and other mood and cognitive effects when administered intravenously (0.1 mg/kg) rather than orally (0.5 mg/kg) to healthy subjects. Nonetheless, similar elevations in peak plasma cortisol and prolactin concentrations were obtained with the two dosage regimens, and temperature elevations were greater after oral m-CPP. Plateau phase plasma concentrations of m-CPP at the times of the maximum neuroendocrine responses to intravenous and oral m-CPP were similar. Since all rodent and nonhuman primate studies have used parenterally administered m-CPP, and previous clinical investigations using intravenous rather than oral m-CPP have yielded somewhat discrepant results, our normative data should be useful for comparing results, our normative data should be useful for comparing results across different human studies and across species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444705
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  • 3
    Electronic Resource
    Electronic Resource
    Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patients (1998)
    Springer
    Psychopharmacology 140 (1998), S. 434-444 
    Details
    ISSN: 1432-2072
    Keywords: Key words Obsessive-compulsive disorder ; Anxiety ; Serotonin reuptake inhibitor ; Serotonin antagonist ; Metergoline ; Fluoxetine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Enhanced serotonergic transmission may underlie therapeutic effects of serotonin reuptake inhibitors in obsessive-compulsive disorder. However, such treatment may decrease serotonin receptor responsivity. We investigated whether the serotonin antagonist metergoline would exacerbate or further improve systems in fluoxetine-responsive patients. Pilot results suggested open metergoline produced delayed symptom worsening in fluoxetine-treated patients. Fourteen patients continuing fluoxetine received metergoline and placebo (double-blind, randomized). Symptom ratings continued for 1 week afterwards. Ten unmedicated patients underwent the same procedures. Symptoms improved 4 h after both metergoline and placebo. The day after metergoline but not placebo, fluoxetine-treated patients had significantly increased anxiety, obsessions and compulsions, abating over several days. Depression was unchanged. Metergoline had no similar delayed effects in unmedicated patients. Metergoline levels were higher in fluoxetine-treated patients. These results, consistent with less conclusive earlier findings, suggest that prolonged changes in brain serotonin function underlie symptom re-emergence following administration of metergoline to fluoxetine-treated patients with obsessive-compulsive disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050787
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  • 4
    Electronic Resource
    Electronic Resource
    The replication origin position and its relationship to a negative trans-acting transcription regulator encoded by Dictyostelium discoideum nuclear plasmid Ddp1 (1995)
    Springer
    Current genetics 27 (1995), S. 479-484 
    Details
    ISSN: 1432-0983
    Keywords: Dictyostelium discoideum ; Negative transcription regulator ; Nuclear plasmid ; Replication origin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The replication origin of the Dictyostelium discoideum plasmid Ddp1 was localized to a 543-bp region. This includes most of the AT-rich intergenic region between the G1 and G5/D6 genes containing both of their promoters and multiple copies of a TTTTGACT repeat. The G5/D6 gene, which lies adjacent to, and partially overlaps, the 543-bp origin region, encodes a trans-acting factor that negatively regulates transcription of the G4/D5 gene. Inactivation of the G5/D6 gene led to expression of a transcript (G6) 0.2 kb larger than the D5 transcript from the G4/D5 gene in vegetative and developing cells. The G5/D6 gene also regulates transcription of the G1, G2/G3/D4 and G5/D6 genes either alone or in concert with other Ddp1 gene products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311219
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  • 5
    Electronic Resource
    Electronic Resource
    Temperature-sensitive DNA repair mutations in the cellular slime mould Dictyostelium discoideum (1981)
    Springer
    Current genetics 3 (1981), S. 167-171 
    Details
    ISSN: 1432-0983
    Keywords: Dictyostelium discoideum ; DNA repair mutations ; Temperature-sensitive DNA repair ; DNA replication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The nonallelic radB13 and radG5 DNA repair mutations lower the plating efficiency at 26.5 °C of unirradiated D. discoideum cells. Revertants selected on the basis of resistance to gamma rays or UV from strains bearing either the radB13 or radG5 mutations are no longer temperature-sensitive at 26.5 °C. Unlike the wild-type and radiation-resistant revertants, survival following UV irradiation is lower at 24.5 °C than at 17.0 °C or 21.0 °C in strains carrying either the radB13 or radG5 mutation. We conclude that the gene products of the radB and radG loci probably affect normal cell growth by affecting DNA metabolism. Seven radiation-sensitive mutations that effect six loci other than radB and radG do not have temperature-sensitive phenotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429818
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  • 6
    Electronic Resource
    Electronic Resource
    Altered neuroendocrine and behavioral responses to m-chlorophenylpiperazine in 3,4-methylenedioxymethamphetamine (MDMA) users (1999)
    Springer
    Psychopharmacology 147 (1999), S. 56-65 
    Details
    ISSN: 1432-2072
    Keywords: Key words Serotonin ; Neurotoxicity ; Mood ; Anxiety ; Cortisol ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: (±) 3,4-Methylenedioxymethamphetamine (MDMA, ”Ecstasy”) is a popular drug of abuse and a brain serotonin neurotoxin in animals. Growing evidence indicates that humans are also susceptible to MDMA’s neurotoxic effects, although few functional consequences of MDMA-induced 5-HT damage have been identified. Objective: The present study sought to determine whether possible differences between MDMA users and control subjects could be unmasked by utilizing a pharmacological challenge with the mixed 5-HT agonist, meta-chlorophenylpiperazine (m-CPP). It was postulated that 5-HT neurotoxicity in MDMA users would be associated with altered 5-HT responsivity, exemplified by altered physiological and behavioral responses to m-CPP. Methods: Twenty-five MDMA users who had not taken MDMA for at least 3 weeks and 25 controls received intravenous placebo (normal saline) and m-CPP (0.08 mg/kg) in a fixed order, single blind design. Repeated measures of mood, physical symptoms, and blood samples for neuroendocrine analyses were collected during the 90 min after each infusion. Results: MDMA users reported more positive and fewer negative emotions and physical symptoms following m-CPP than controls, and were significantly less likely to report an m-CPP-induced panic attack. Male MDMA users had diminished cortisol and prolactin responses to m-CPP. Conclusions: The present data indicate that MDMA users have alterations in 5-HT neuronal function, possibly as a consequence of MDMA-induced brain serotonin neural injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130051142
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  • 7
    Electronic Resource
    Electronic Resource
    Linkage analysis of the myosin heavy chain gene in Dictyostelium discoideum using a mutation generated by homologous recombination (1989)
    Springer
    Molecular genetics and genomics 216 (1989), S. 498-502 
    Details
    ISSN: 1617-4623
    Keywords: Dictyostelium discoideum ; Myosin ; Linkage analysis ; Gene disruption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A mutation (mhcA1 in strain HMM) created by insertional gene inactivation was used to map the Dictyostelium discoideum myosin heavy chain gene (mhcA) to linkage group IV. Three phenotypic traits associated with this mutation (slow colony growth, inability of the mutant to develop past aggregation, and the presence of five to ten integrated vector copies) cosegregated as expected for the consequences of a single insertional event. This linkage was confirmed using a restriction fragment length polymorphism. The mhcA1 mutation was recessive to wild type and was nonallelic with mutations at the following loci on linkage group IV: aggJ, aggL, couH, minA, phgB and tsgB. This work demonstrates the ability to apply standard techniques developed for D. discoideum parasexual genetic analyses to mutants generated by transformation, which is of particular relevance to analysis of genes for which no classical mutations or restriction fragment length polymorphisms are available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334396
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  • 8
    Electronic Resource
    Electronic Resource
    Gene amplification associated with the dominant cob-354 cobalt resistance trait in Dictyostelium discoideum (1989)
    Springer
    Molecular genetics and genomics 220 (1989), S. 25-32 
    Details
    ISSN: 1617-4623
    Keywords: Dictyostelium discoideum ; Cobalt resistance ; Gene amplification ; Extrachromosomal ; Developmental defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A DNA amplification is correlated with the dominant, unstable cob-354 cobalt resistance trait in the cellular slime mold, Dictyostelium discoideum. The amplified DNA is present as about 50 copies of an extrachromosomal element. Cells grown under nonselective conditions in the absence of cobalt ions lose both the cobalt resistance trait and all extrachromosomal copies of the amplified DNA. The amplified DNA is transferrable to new genetic backgrounds by parasexual genetic crosses. These results explain the inability to map the cob-354 trait to a linkage group. The chromosomal origin of the amplified DNA is group III or VI. Thus the resistance trait appears to be independent of the previously known cobalt resistance locus, cobA, which maps to group VII. A developmental defect involving the production of multiply-tipped aggregates that do not complete fruiting body formation also is correlated with the presence of the amplified DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00260851
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  • 9
    Electronic Resource
    Electronic Resource
    Chromosomal mapping of tRNA genes from Dictyostelium discoideum (1987)
    Springer
    Molecular genetics and genomics 207 (1987), S. 176-187 
    Details
    ISSN: 1617-4623
    Keywords: Dictyostelium discoideum ; Restriction fragment length polymorphism ; tRNA genes ; Chromosomal organization ; Milti-copy genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Different wild-type isolates of Dictyostelium discoideum exhibit extensive polymorphism in the length of restriction fragments carrying tRNA genes. These size differences were used to study the organisation of two tRNA gene families which encode a tRNAVal(GUU) and a tRNAVal(GUA) gene. The method used involved a combination of classitics. The tRNA genes were mapped to specific linkage groups (chromosomes) by correlating the presence of polymorphic DNA bands that hybridized with the tRNA gene probes with the presence of genetic markers for those linkage groups. These analyses established that both of the tRNA gene families are dispersed among sites on several of the chromosomes. Information of nine tRNAVal(GUU) genes from the wild-type isolate NC4 was obtained: three map to linkage group I (C, E, F,), two map to linkage group II (D, I), one maps to linkage group IV (G), one, which corresponds to the cloned gene, maps to either linkage group III or VI (B), and two map to one of linkage groups III, VI or VIII (A, H). Six tRNAVal(GUA) genes from the NC4 isolate were mapped; one to linkage group I (D), two to linkage group III, VI or VII (B, C) and three to linkage group VII or III (A, E, F).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331507
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  • 10
    Electronic Resource
    Electronic Resource
    Mutations specific to spore maturation in the asexual fruiting body of dicytostelium discoideum (1979)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 1 (1979), S. 355-362 
    Details
    ISSN: 0192-253X
    Keywords: Dictyostelium discoideum ; spore maturation ; spore specific mutations ; cell patterning ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Three mutations affecting spore maturation in the asexual fruiting body of Dictyostelium discoideum are assigned to a new locus, sprJ, on linkage group IV. Strains carrying mutations at the sprJ locus do not form mature spores, yet the cell patterning (spore, stalk and disc cell ratios) is apparently normal. These mutations will be useful to delineate branch points between the cell patterning and spore maturation pathways. There are some unusual features of the sprJ-containing mutants. In particular each of the parent strains of the three mutants has incomplete spore maturation as determined by colony-forming ability after heat shocking at 45°C. A mutation allowing growth in the presence of benlate (600 μg/ml), benA351, is mapped to linkage group I.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020010408
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