ISSN:
1432-2072
Keywords:
Corticotropin-releasing factor
;
Startle
;
Chlordiazepoxide
;
Anxiety
;
Strychnine
;
Amphetamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A series of experiments was performed to investigate the effects of corticotropin-releasing factor (CRF) on the amplitude of the acoustic startle response (ASR) in rats. Intracerebroventricular (ICV) administration of 1 μg rat CRF significantly potentiated acoustic startle amplitude; these effects were reversed in a dose-dependent manner by pretreatment with the benzodiazepine chlordiazepoxide (CDP). Doses of CDP that anatgonized CRF-potentiated ASR did not lower startle baseline or antagonize amphetamine-or strychnine-potentiated ASR. These results suggest that CRF has “anxiogenic” properties and may serve as a neuroendocrine modulator of stress-enhanced behaviors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00652231
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