Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Comparison of acute alprazolam (0.25, 0.50 and 1.0 mg) effects versus those of lorazepam 2 mg and placebo on memory in healthy volunteers using laboratory and telephone tests (1995)
    Springer
    Psychopharmacology 118 (1995), S. 1-9 
    Details
    ISSN: 1432-2072
    Keywords: Alprazolam ; Lorazepam Dose-effect relationship ; Healthy volunteers Memory ; Cognitive functioning ; Telephone tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was designed to confirm the hypothetical dose-dependent effect of alprazolam on memory and to compare its effects on tests measuring different aspects of cognitive and psychomotor functioning. A secondary purpose was to compare the sensitivity of newly developed telephone tests with a standard laboratory test of memory. Twenty healthy male volunteers (aged 18–35 years) participated in a five-way double-blind crossover design. Treatments were single oral doses of alprazolam (0.25, 0.5 and 1.0 mg), placebo and lorazepam 2.0 mg. The latter was included as an internal control for demonstrating sensitivity of the method. Lorazepam significantly impaired all performance measures except two: verbal fluency and accuracy of music recognition were insensitive to drug effects. Alprazolam had clear dose-dependent effects on different aspects of memory: 0.25 mg did not affect any parameter; 0.5 mg impaired performance in a Word Learning Test and a Spatial Memory Test and also psychomotor performance; 1.0 mg additionally impaired Syntactic Reasoning, Semantic Verification, and Critical Flicker Fusion performance. Alprazolam's effects were not selective for any of the cognitive functions as measured in this study. The telephone tests were clearly less sensitive than the standard test, though sufficient for showing significant effects of alprazolam 1 mg and lorazepam 2 mg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245243
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Turbulence downstream from the Ionescu-Shiley bioprosthesis in steady and pulsatile flow (1987)
    Springer
    Medical & biological engineering & computing 25 (1987), S. 645-649 
    Details
    ISSN: 1741-0444
    Keywords: Aortic prosthesis ; Artificial heart valve ; Bioprosthesis ; Ionescu-Shiley ; Laser-Doppler anemometry ; Pulsatile flow ; Shear stress ; Steady flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The turbulence generated downstream from an aortic Ionescu-Shiley bioprosthesis has been investigated in vitro with both steady and pulsatile flow; Instantaneous point velocities were measured using laser-Doppler anemometry (LDA) at numerous preselected locations in the flow. The mean and RMS velocities from these data at each location were then used to estimate the laminar and turbulent shear in the bulk flow as a function of radial position on a cross-section of the flow system downstream from the mounted prosthesis. Estimated total shear stresses were found in the bulk flow that were of sufficient magnitude to possibly cause haemolysis and initiate platelet chemical-release reactions. For steady flow and at peak pulsatile flow, maximum total shear stresses were estimated to be 120 N m−2 and 100 N m−2, respectively, over more than 5 per cent of the flow cross-section. The spatial distribution of the elevated shear stresses correlates well with the valve superstructure. It is concluded that these elevated stresses are a direct consequence of the notable flow constriction generated by the valve’s fully opened leaflets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447332
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...