ISSN:
1573-6873
Keywords:
bistability
;
bursting
;
ion channels
;
modulation
;
nonlinear dynamics
;
Aplysia
;
R15
Source:
Springer Online Journal Archives 1860-2000
Topics:
Computer Science
,
Medicine
,
Physics
Notes:
Abstract In a computational model of the bursting neuron R15, we have implemented proposed mechanisms for the modulation of two ionic currents (I R andI SI) that play key roles in regulating its spontaneous electrical activity. The model was sufficient to simulate a wide range of endogenous activity in the presence of various concentrations of serotonin (5-HT) or dopamine (DA). The model was also sufficient to simulate the responses of the neuron to extrinsic current pulses and the ways in which those responses were altered by 5-HT or DA. The results suggest that the actions of modulatory agents and second messengers on this neuron, and presumably other neurons, cannot be understood on the basis of their direct effects alone. It is also necessary to take into account the indirect effects of these agents on other unmodulated ion channels. These indirect effects occur through the dynamic interactions of voltage-dependent and calcium-dependent processes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00962706
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