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  • Chemistry  (8)
  • Apomorphine  (3)
  • Cholinergic  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Dopaminergic supersensitivity: Influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia (1979)
    Springer
    Psychopharmacology 62 (1979), S. 111-116 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Neuroleptics ; Supersensitivity ; Mice ; Apomorphine ; Cholinergic ; Anticholinergic ; GABA-agonists ; Benzodiazepines ; Barbiturates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Single and repeated administration of neuroleptics induce supersensitivity to dopamine agonists like apomorphine and methylphenidate. The degree of this supersensitivity depends on the period of the preceding administration of the neuroleptic. In the development phase additional administration of apomorphine can reverse the hyperdopaminergic behaviour, whereas addition of cholinergic/anticholinergic treatment does not modify the enhanced receptor response. In the supersensitivity phase additional treatment with deanol does not modify the supersensitivity. Phenobarbital, diazepam, and muscimol increase and cis (Z)-flupenthixol decreases the supersensitivity. It is concluded that supersensitivity induced by neuroleptics is time-dependent and that it can be prevented by additional treatment with DA-agonists but not by cholinergic/anticholinergic treatment. In the supersensitivity phase, the syndrome is suppressed by dopamine antagonists but enhanced by GABA-agonists, benzodiazepine and phenobarbital.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00427122
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  • 2
    Digitale Medien
    Digitale Medien
    Influence of flupenthixol and flupenthixol-decanoate on methylphenidate and apomorphine-induced compulsive gnawing in mice (1974)
    Springer
    Psychopharmacology 34 (1974), S. 119-126 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Psychopharmacology ; Flupenthixol ; Flupenthixol-Decanoate ; Mice ; Methylphenidate ; Apomorphine ; Compulsive Behaviour
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract α-Flupenthixol and α-flupenthixol decanoate were tested in mice against methylphenidate-induced stereotyped gnaw-compulsions. The effect of both α-flupenthixol, and α-flupenthixol decanoate disappeared 2 days after administration. In addition, the influence of α-flupenthixol and α-flupenthixol decanoate on the apomorphine-induced behaviour in mice was followed over a period of 12 days. Under these conditions apomorphine-induced compulsive gnawing was seen on the days on which the methylphenidate antagonistic effect had subsided. The apomorphine-induced compulsive gnawing seen in α-flupenthixol and α-flupenthixol decanoate pretreated animals could be antagonized by additional small doses of α-flupenthixol given 2 h before apomorphine. The interference of the neuroleptic drugs with dopaminergic receptors is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00421936
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  • 3
    Digitale Medien
    Digitale Medien
    On the supersensitivity of dopamine receptors, induced by neuroleptics (1976)
    Springer
    Psychopharmacology 48 (1976), S. 1-6 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Neuroleptics ; Supersensitivity ; Dopamine receptors ; Compulsive behavior ; Mice ; Apomorphine ; Methylphenidate ; Synthesis inhibition ; Cholinergic ; Anticholinergic
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Different neuroleptics caused dopamine receptor blockade (antagonism against methylphenidate-induced compulsive gnawing) for varying lengths of time. When the receptor blockade had expired, supersensitivity to dopamine agonists (occurrence of apomorphine-induced compulsive gnawing and enhancement of methylphenidate-induced gnawing) developed and persisted for varying periods of time. The degree and duration of supersensitivity was related to the degree and duration of the preceding receptor blockade. Inhibition of catecholamine or 5-HT synthesis had no influence on development of supersensitivity. Stimulation with a dopamine agonist, apomorphine, during the period of the development of supersensitivity did not modify the enhanced receptor supersensitivity. A cholinergic-dopaminergic balance was shown to be involved in the manifestation of compulsive behavior during the supersensitivity phase. Tolerance to the dopamine antagonistic effect of a neuroleptic also developed after a single neuroleptic treatment, most likely due to increased sensitivity of the receptors for the dopamine agonist. It is concluded, that the dopamine receptor blockade induced by a single dose of a neuroleptic agent is a dynamic phenomenon which in the course of time is replaced by an increased sensitivity of the receptors to dopamine agonists. Noradrenergic or 5-HT neuron systems do not seem to be involved in the neuroleptic-induced supersensitivity, whereas a dopaminergic-cholinergic balance is operative in the supersensitivity situation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00423298
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  • 4
    Digitale Medien
    Digitale Medien
    Über die Reaktion zwischen Herapathit und kohlensaurem Baryt in verdünntem Alkohol (1897)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 14 (1897), S. 297-301 
    Details
    ISSN: 0863-1778
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.18970140125
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  • 5
    Digitale Medien
    Digitale Medien
    Über Verbindungen der Chlorhydrate der Alkaloïde mit höheren Metallchloriden und über entsprechende Bromverbindungen (1906)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 74 (1906), S. 161-187 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19060740114
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  • 6
    Digitale Medien
    Digitale Medien
    Ueber Perbromide von Chinaalkaloïden (1901)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 63 (1901), S. 313-351 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19010630116
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  • 7
    Digitale Medien
    Digitale Medien
    Über Bromderivate von Chinaalkaloïden und über die entsprechenden wasserstoffärmeren Verbindungen (1903)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 68 (1903), S. 425-448 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19030680131
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  • 8
    Digitale Medien
    Digitale Medien
    Über Bromderivate von Chinaalkaloïden und über die entsprechenden wasserstoffärmeren Verbindungen (1904)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 69 (1904), S. 193-222 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19040690114
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  • 9
    Digitale Medien
    Digitale Medien
    Über Dibromadditionsprodukte der Chinaalkaloïde (1904)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 71 (1904), S. 1-29 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19040710101
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  • 10
    Digitale Medien
    Digitale Medien
    Conformational studies of peptides. The crystal structures of N-acetyl-L-prolinamide and N-acetyl-(S)-thiazolidine-4-carboxamide (1976)
    New York : Wiley-Blackwell
    Biopolymers 15 (1976), S. 2523-2534 
    Details
    ISSN: 0006-3525
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The crystal structure of N′-acetyl-L-prolinamide and its isomorphous alalog N′-acetyl-(S)-thiazolidine-4-carboxamide was determined using highly accurate parameters obtained by room- and low-temperature data-collecting systems. Both crystals are orthorhombic, space group P212121, with four molecules per unit cell held together by a hydrogen-bond system that extends in all directions.Both molecules exhibit the following conformational features: the acetyl group is in the trans configuration in respect to the tertiary amide. The primary amide is almost at right angles with respect to the mean plane of the ring and the -NH2 group is over the ring. The pyrrolidine and thiazolidine rings were found to be rather flexible with Cβ puckering in the former and sulfur in the latter.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bip.1976.360151213
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