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  • 1
    Electronic Resource
    Electronic Resource
    Does conditioned nausea mediate drug-induced conditioned taste aversion? (1982)
    Springer
    Psychopharmacology 78 (1982), S. 277-281 
    Details
    ISSN: 1432-2072
    Keywords: Conditioned taste aversion ; Scopolamine ; Prochlorperazine ; Lithium ; Amphetamine ; Morphine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two antiemetic drugs were tested on the expression of taste aversions previously conditioned in rats with lithium, amphetamine or morphine. Neither prochlorperazine nor scopolamine administered prior to testing attenuated established aversions, although both drugs are known to have antiemetic effects in other species. Negative findings were obtained with a range of doses of prochlorperazine and scopolamine, with strong and weak aversions, with one- and two-stimulus tests, in a repeated one-stimulus extinction procedure, with between- and within-group designs and with hooded, albino, male and female rats. The results do not support the widely accepted hypothesis that conditioned nausea mediates conditioned taste aversion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428165
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Role of training conditions in discrimination of central nervous system stimulants by rats (1981)
    Springer
    Psychopharmacology 73 (1981), S. 295-303 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Cocaine ; Apomorphine ; p-Hydroxyamphetamine ; Drug discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amphetamine and some related compounds were compared in rats trained to discriminate (+)-amphetamine (0.4,1.0 or 1.6 mg/kg) or cocaine (10.0 mg/kg) from the nondrug condition in a standard, two-bar procedure with food reinforcement (n=5–6). Amphetamine and cocaine were generalized completely with each other, in most cases at dose levels which did not greatly reduce the overall numbers of responses. The ED50 values for amphetamine and cocaine varied with the drug and dose used for training, and it was concluded that the stimuli produced by the two drugs were similar but may not be identical. There was an excellent correlation between ED50 values derived from indices of barselection and percentage-responding on the drug-appropriate bar. Apomorphine was generalized with amphetamine only in the rats trained with the higher doses of amphetamine, and only when administered in doses which greatly reduced the overall number of responses. Para-hydroxyamphetamine increased responding on the drug-appropriate bar only when administered in high doses to the rats trained with the lowest dose of amphetamine (0.4 mg/kg). The results strengthen the evidence that the particular drug and dose level used for training can significantly affect the outcome of generalization tests, and challenge the notion that the discriminability of drugs is an immutable property that is amenable to absolute measurement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422421
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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