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  • 1
    Electronic Resource
    Electronic Resource
    Freshwater snails of Oman, South Eastern Arabia (1985)
    Springer
    Hydrobiologia 127 (1985), S. 125-149 
    Details
    ISSN: 1573-5117
    Keywords: Mollusca ; Gastropoda ; freshwater snails ; Arabia ; Oman ; schistosomiasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A systematic account is given of the extant freshwater snail fauna of Oman, based on recent collections made in Dhofar and in the northern mountainous areas. Also included are certain species found in brackish coastal localities. A total of 8 freshwater species is regarded as belonging to the fauna of normal freshwater; 7 have been found alive (Thiara scabra, Melanoides tuberculata, Lymnaea natalensis, Gyraulus piscinarum, Biomphalaria arabica, Bulinus wrighti and Indoplanorbis exustus) and one is known only as shells (Paludestrina glaucovirens). This report of G. piscinarum is the first for Oman and may be the first reliable identification for Arabia. Three taxa from brackish water, Gangetia miliacea, Iravadia quadrasi and Melanoides sp., are new for the fauna of Oman and of the whole Arabian peninsula. The finding of G. miliacea provides the first instance of any member of the Stenothyridae living west of the Gulf of Oman and identified from whole snails rather than empty shells. I. quadrasi is the first member of its genus to be found alive west of the Gulf of Oman.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00004192
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  • 2
    Electronic Resource
    Electronic Resource
    Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines (1996)
    Springer
    Breast cancer research and treatment 38 (1996), S. 67-73 
    Details
    ISSN: 1573-7217
    Keywords: epidermal growth factor ; EGF receptor ; quinazolines ; IGF-I ; TGFα ; tyrosine kinase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since the mitogenic action of EGF is mediated by ligand-induced autophosphorylation of the EGF receptor (EGFR), and EGFR is commonly overexpressed in solid human tumours, inhibitors of receptor tyrosine kinase activity (RTK) could prove to be effective antitumour agents. Screening of a compound library using an EGF-RTK enzyme prepared from human tumour derived A431 cells identified a series of potent (IC50〈1µM) enzyme inhibitors. These inhibitors are quinazolines bearing a variety of substituted anilines at the 4-position. The most potent 4-anilinoquinazolines (IC50 ≅ 20nM) have small non-polar meta substituents on the aniline ring, and are competitive with ATP and non-competitive with substrate. The growth inhibitory activity of these agents was assessed in vitro using KB cells (human oral squamous tumour) grown in the absence or presence of EGF. A selected compound, 4-(3-chloroanilino)quinazoline (CAQ), inhibited EGF-stimulated growth in a concentration dependent manner and complete blockade was observed at concentrations (1–10 µM) which had no effect on basal growth. Selectivity of growth inhibition by CAQ was further exemplified in IGF1-stimulated KB cells where no effect was detected at concentrations which completely blocked EGF-stimulated growth. Similarly, CAQ blocked TGFα-stimulated growth in MCF-7 human breast cancer cells without affecting insulin-stimulated growth. These studies define a novel class of EGF-RTK inhibitors which are also potent and selective inhibitors of EGF-stimulated human tumour cell growthin vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01803785
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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