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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 1102-1107 
    ISSN: 1432-1440
    Keywords: Anorexia ; Aromatic amino acids ; Branched-chain amino acids ; Dopaminergic neurons ; Neoplastic diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies in anorectic tumor-bearing rats indicate that anorexia is correlated to imbalances of neutral amino acids in blood and CNS. Consequently plasma amino acids of patients with neoplastic and non-neoplastic internal diseases were studied during phases of anorexia; special regard was given to the precursors of dopamine and serotonin. Anorectic patients were compared to non-anorectic patients with neoplasia. During anorexia, plasma levels of valine and leucine and hence the ratio of the molar concentrations of Val+Leu+Ile/Phe+Tyr were significantly decreased in each anorectic patient as compared to non-anorectic patients whose ratios were always within the normal ranges. As aromatic and branched-chain amino acids compete for penetration of the blood brain barrier, the decrease of the amino acid ratio may induce a raised flux of phenylalanine and tyrosine into the CNS which results in an increased activation of dopaminergic neurons — known to cause anorexia.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 307 (1981), S. 404-408 
    ISSN: 1618-2650
    Keywords: Ionenselektive Disk-Elektrode ; Chloridselektive Elektrode ; Chloridbestimmung im Blut
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Messung von Chlorid im heparinisierten Blut mit einer ionenselektiven Disk-Elektrode im strömungsoptimierten Durchflußsystem wird vergleichend anderen etablierten Meßverfahren der klinischen Chemie für Cl−-Messungen im Serum, wie Coulometrie und Mercurimetrie, gegenübergestellt. Eine gute Korrelation dieser Methoden wird demonstriert. Die direkte Blutmessung von Cl− vermeidet Meßwertverfälschungen durch Probenaufbereitung oder wie sie bei Messungen mit ionenselektiven Kristallmembranelektroden in Serumproben durch lange Stehzeiten auftreten können. Die Kalibrierung erfolgt durch wäßrige NaCl-Lösungen unter Hydrogencarbonatzusatz. Meßkurven dokumentieren die Potentialstabilität.
    Notes: Summary The measurement of chloride in heparinized blood by means of an ion-selective disc electrode in a flow-optimized flow-through system is compared with other established methods in clinical chemistry for Cl− measurements in serum, e.g. coulometry and mercurimetry. The methods are shown to correlate well. The direct blood measurement of Cl− prevents falsification of data due to sample preparation or due to long retention periods such as may occur in serum samples with measurements using ion-selective crystal membrane electrodes. Calibration is effected by means of aqueous solutions of NaCl under addition of hydrogencarbonate. Graphs prove the stability of potential.
    Type of Medium: Electronic Resource
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