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  • 1
    Electronic Resource
    Electronic Resource
    Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro (1980)
    Springer
    Archives of dermatological research 267 (1980), S. 91-95 
    Details
    ISSN: 1432-069X
    Keywords: Arsenic ; SCE ; Lymphocytes ; Arsen ; SCE ; Lymphocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Zahl von »sister chromatid exchanges« (SCE) pro Metaphase wurde mit der Hoechst-Giemsa Technik an menschlichen Lymphocyten bestimmt. Die Zugabe von anorganischem trivalenten Arsen (Na2HAsO4) 10-6 M und 2x10-6 M zeigt einen signifikanten und dosisabhängigen Anstieg der SCE. Dieses Phänomen ist ebenso empfindlich wie der Nachweis von Chromosomenaberrationen der Lymphocyten durch Arsenexposition in vitro.
    Notes: Summary The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10-6M and 2x10-6 M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitive as the evidence of arsenic-induced chromosomal aberrations in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00416927
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of Merkel cells in acute UVB erythema (1992)
    Springer
    Archives of dermatological research 284 (1992), S. 271-274 
    Details
    ISSN: 1432-069X
    Keywords: Merkel cells ; UVB erythema ; Cytokeratins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Merkel cells (MC) were identified immunohistochemically using antibodies specific for cytokeratin (CK) 20 within human epidermis 12 to 72 h after exposure to UVB (4 MED). 12 h after exposure all MC were normally localized within the epidermal basal layer. However, 24 h after exposure 4% of the MC were detected suprabasally, the remaining 96% still being situated in the basal layer. Surprisingly, at 48 h and 72 h more than 50% had lost contact with the basal membrane. The MC of hair follicles did not show any obvious changes. These results argue, in the context of acute epidermal UV damage, for an abnormal turnover in dermatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372580
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 213-216 
    Details
    ISSN: 1432-069X
    Keywords: Merkel cells ; Actinic skin damage ; Cytokeratins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Merkel cells (MCs), the neuroendocrine cells of the skin cannot be identified with certainty using conventional light microscopic staining methods. Using immunoperoxidase microscopy with antibodies specific for cytokeratin 18, which has been established as a marker protein of MCs, we have evaluated the numbers of MCs per mm2 skin in normal and sun-damaged upper arm skin. The sun-exposed skin contained twice as many MCs as the not sun exposed skin. Further quantification of MC density at various body sites (trunk, leg) showed a rather variable but often unexpectedly high MC density. The possible role of MC in development of actinic elastosis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371638
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    Paper (German National Licenses)
    Fulltext
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