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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 267 (1980), S. 91-95 
    ISSN: 1432-069X
    Keywords: Arsenic ; SCE ; Lymphocytes ; Arsen ; SCE ; Lymphocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Zahl von »sister chromatid exchanges« (SCE) pro Metaphase wurde mit der Hoechst-Giemsa Technik an menschlichen Lymphocyten bestimmt. Die Zugabe von anorganischem trivalenten Arsen (Na2HAsO4) 10-6 M und 2x10-6 M zeigt einen signifikanten und dosisabhängigen Anstieg der SCE. Dieses Phänomen ist ebenso empfindlich wie der Nachweis von Chromosomenaberrationen der Lymphocyten durch Arsenexposition in vitro.
    Notes: Summary The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10-6M and 2x10-6 M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitive as the evidence of arsenic-induced chromosomal aberrations in vitro.
    Type of Medium: Electronic Resource
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