ISSN:
1432-2013
Keywords:
Hypertension
;
Ventricular afterload
;
Cardiac hypertrophy
;
Arterial impedance
;
Pulsatile haemodynamics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In hypertensive animals and humans, cardiac hypertrophy may occur as a consequence of an external load on the heart. Several studies have suggested that the non-pulsatile components of arterial haemodynamics, such as arterial pressure and vascular resistance, do not adequately represent the ventricular afterload and are not well correlated with the degree of cardiac hypertrophy (CH). The present study was undertaken to analyse the correlation between the degree of CH and various haemodynamic parameters in the spontaneously hypertensive rat (SHR) with established hypertension. A total of 36 SHRs (6–8 months) with a tail-cuff pressure above 190 mm Hg were used. Control data were obtained from 32 age-matched normotensive Wistar Kyoto rats (WKY). Animals were anaesthetized with pentobarbitone sodium (40 mg/kg i.p.) and artificially ventilated with a respirator. A Millar catheter with a high-fidelity pressure sensor was used to record the aortic pressure and an electromagnetic flow transducer to monitor the aortic flow. The pressure and flow signals were subjected to Fourier transformation for the analysis of the arterial impedance spectrum. The left ventricular weight-to-body weight ratio (LVW/BW) was taken as a measure of the degree of CH. The measured haemodynamic parameters in these anaesthetized, open-chest SHRs were systolic pressure (SP) (mean ± SE) 172±4 mm Hg, diastolic pressure (DP), 120±3 mm Hg, pulse pressure (PP) 52±2 mm Hg, peripheral resistance (R p) 344,032±8,012 dyne · s · cm−5, characteristic impedance (Zc) 6,442±313 dyne · s · cm−5, the impedance modulus at the first harmonic (Z1) 26,611±1,061 dyne · s · cm−5, mean arterial compliance (C m) 0.87 ±0.04 μl/mm Hg and LVW/BW 3.092±0.026 mg/g. These parameters were significantly greater than the corresponding values in WKY, except that C m was much decreased. In SHR, the LVW/BW was not significantly correlated with the SP, DP, R p and steady external power. In contrast, the degree of CH was positively correlated with Zc (r=0.66, P〈0.001), Z1 (r=0.62, P〈0.001) and pulsatile external work (r=0.41, P〈0.05). It was also positively correlated with the backward pressure wave (r=0.42, P〈0.05) and negatively correlated with C m (r=-0.72, P〈0.01). Such correlations of LVW/BW with pulsatile haemodynamics were not found in the normotensive WKY. The results indicate that the degree of cardiac hypertrophy in hypertensive rats, with a high blood pressure and increased stiffness of the arterial tree, is more closely related to pulsatile arterial haemodynamics than to the nonpulsatile components.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00374575
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