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  • 1
    Electronic Resource
    Electronic Resource
    Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 562-564 
    Details
    ISSN: 1432-1076
    Keywords: Key words Valproate ; Mitochondrial encephalomyopathy ; MELAS syndrome ; Mitochondrial mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report in this study a patient who developed repeated convulsions as a result of valproate therapy. MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) was subsequently diagnosed and a nucleotide 3243 A→G mutation was detected in the mitochondrial DNA. This mutation predisposes the patient to the detrimental effects of valproate on oxidative phosphorylation. Conclusion We support the suggestion of Ponchaut et al. [14] that valproate should not be given to patients suspected of having mitochondrial diseases. In addition, for patients whose seizures worsen with valproate therapy, an inborn error of mitochondrial metabolism should be suspected. The underlying mitochondrial DNA defects should be sought for family screening and genetic counselling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050663
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  • 2
    Electronic Resource
    Electronic Resource
    Aspergillus terreus and fescue toxicosis (1989)
    Springer
    Plant and soil 119 (1989), S. 177-180 
    Details
    ISSN: 1573-5036
    Keywords: Acremonium coenophialum ; Aspergillus terreus ; fescue toxicosis ; fescue foot ; summer syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The incidence ofAspergillus terreus recovered fromAcremonium coenophialum-infected and non-infected tall fescue grass and from the rumens of heifers grazing on the grasses was determined. The recovery ofA. terreus fromA. coenophialum-infected grass was similar to that from non-infected grass. The same was true of the recovery from the rumens of heifers on infected and non-infected grass. All heifers grazing onA. coenophialum-infected grass showed symptoms of the summer syndrome manifestation of fescue toxicosis while those grazing on non-infected grass did not;A. terreus is not a factor in fescue toxicosis in cattle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02370282
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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