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  • Assessment of relatives  (1)
  • Double-Blind Multicentre Study  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Arthropathie bei der idiopathischen Hämochromatose (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1199-1207 
    Details
    ISSN: 1432-1440
    Keywords: Hemochromatosis arthropathy ; Nosology ; Tissue typing ; Assessment of relatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 22 of 35 patients (63%) with idiopathic hemochromatosis arthropathy could be demonstrated. In 20 patients the metacarpophalangeal joints (mainly II and III) with preference of the right hand were affected. Chondrocalcinosis of the wrist and knee was found both in two patients with metacarpophalangeal joint disease and in two patients without metacarpophalangeal disease. Further joints affected were the wrists (14), the other finger joints (11), and the knees (6). The dominant clinical complaint was pain in motion. Swelling and redness were rare findings only in case of acute exacerbations. The radiologic changes in the metacarpophalangeal joints were narrowing of the joint spaces, subchondral cysts, sclerosis of subchondral bone of metacarpal heads, and marginal osteophytic appositions at the joints. In one third of the patients arthropathy was evident before the diagnosis of idiopathic hemochromatosis was made. Histocompatibility testing confirmed that HLA-A3 is significantly more frequent in patients with idiopathic hemochromatosis than in normal persons. A statistically significant difference concerning HLA-phenotypes between patients with arthropathy and patients without arthropathy could not be detected. There was no case of arthropathy when 98 relatives of the patients were examined. However, idiopathic hemochromatosis was first detected in ten persons of this group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537431
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of cyclosporin A and azathioprine in the treatment of rheumatoid arthritis — Results of a double-blind multicentre study (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 248-255 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Cyclosporin A ; Azathioprine ; Double-Blind Multicentre Study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective randomized double-blind multicentre study cyclosporin A (CyA) and azathioprine (AZA) were compared in 117 patients with rheumatoid arthritis (starting dose CyA 5 mg/kg, AZA 1.5–2 mg/kg). The six-month treatment period was similarly completed in 92 patients with good clinical results in both groups (mean improvement rate CyA vs. AZA: Ritchie-Index 8.2 vs. 7.7, morning stiffness 41.6 vs. 28.4 min., grip strength 10.9 vs. 15.2 mmHg, swollen joint count 28.9 vs. 27.9%). Treatment was discontinued prematurely in 12 patients in each group (CyA: 2 deaths not related to drug, 1 lack of effect, 9 adverse reactions — AZA: 2 drop-outs, 1 lack of effect, 9 adverse reactions). Altogether effectivity and tolerability were equal in both treatment groups with the exception of an increase in blood pressure and serum creatinine which occurred only in the CyA group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02249021
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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