ISSN:
1420-908X
Keywords:
Org 20241
;
Rolipram
;
Eosinophilia
;
Asthma
;
Brown-Norway rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We examined the effect of a type IV (rolipram) and a combined type III and IV (Org 20421) isoenzymeselective phosphodiesterase inhibitor upon allergeninduced pulmonary eosinophil recruitment in sensitised Brown Norway rats. Rats were sensitised with ovalbumin intraperitoneally and later challenged with ovalbumin aerosol which induced a significant increase in the total eosinophil and neutrophil count in bronchovalveolar lavage fluid at 24 hours (from 0.38 ± 0.12 to 1.36 ± 0.18 × 106,p 〈 0.01 and from 0.06 ± 0.01 to 0.33 ± 0.07 × 106,p 〈 0.01) respectively. Pretreatment with rolipram (30 µmol/kg) and Org 20421 (30 µmol/kg) abolished the eosinophilia and neutrophilia evoked by ovalbumin. We conclude that type IV and possibly type III isozyme phosphodiesterase inhibitors may regulate, directly or indirectly, eosinophil and neutrophil activity and/or those cells responsible for attracting them into the lung.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01793218
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