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  • 1
    Electronic Resource
    Electronic Resource
    Etude Ultrastructurale des Lésions Cérébrales de la Sclérose Tubéreuse de Bourneville (1973)
    Springer
    Acta neuropathologica 25 (1973), S. 259-270 
    Details
    ISSN: 1432-0533
    Keywords: Tuberous Sclerosis ; Electron Microscopy ; Cerebral Biopsy ; Astrocytes ; Cerebral Tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electron microscopic study of a cortical biopsy from a child presenting a Tuberous Sclerosis shows the importance of the astrocytic gliosis, the existence of abnormal cells of which two types can be recognized, and the presence of giant cells. All these cells are remarkable by the abundance of the ergastoplasm, the development of the Golgi apparatus, and the presence of membrane bound dense bodies. These cells are undoubtedly of astrocytic origin and appear very similar to the cells observed in a tumour of the caudate nucleus of another child affected by the same disease. These morphological data lead to believe that the cerebral abnormalities of the Tuberous Sclerosis essentially concern the astrocytes. The main characteristic of this astrocytic lesion would be its blastomatous potentiality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691754
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of intravenous bisoprolol in obese and non-obese volunteers (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 171-174 
    Details
    ISSN: 1432-1041
    Keywords: Bisoprolol ; pharmacokinetics ; obesity ; blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a single i. v. dose of dlbisoprolol 0.16 mg·kg−1 ideal body weight has been studied in 8 obese women (mean weight 91 kg; 161% of ideal body weight) and 8 non-obese women (51 kg; 94% of ideal body weight). Compared to the controls, the obese subjects showed an increase in the total apparent volume of distribution (Vz) (182 vs 135 1) and a decrease in Vz per kg body weight (2 vs 2.7 l·kg−1). There was a negative correlation between Vz l·kg−1 and the percentage of ideal body weight (r=−0.672). Total body clearance was increased, but t1/2 and renal clearance was unchanged. It is concluded that tissue diffusion of bisoprolol in obese subjects is limited, despite its lipophilicity, possibly because of alteration in the blood flow to adipose tissue produced by bisoprolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265912
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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