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  • 1
    Electronic Resource
    Electronic Resource
    Node-like axonal specialisations along demyelinated central nerve fibres: Ultrastructural observations (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 291-296 
    Details
    ISSN: 1432-0533
    Keywords: CNS ; Node of Ranvier ; Demyelination ; Astrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural examination of long-term (1 month to 1 year) demyelinated axons of the central nervous system (CNS) has revealed the presence of certain features typical of nerve fibres at the node of Ranvier. Focal regions of dense undercoating of the axolemma were observed and these always extended along regions which were intimately associated with the processes of gial cells. In many cases the glial cells were astrocytes, but in some cases the cells resembled Schwann cells. The astrocytic and Schwann cell processes were sometimes finger-like and they thus resembled the normal projections of these cells onto the nodal axolemma of central and peripheral nerve fibres, respectively. Since the undercoated regions which were associated with astrocytic processes were also often remote from any oligodendrocyte or Schwann cell processes, it seems that certain node-like specialisations may form or be sustained in the absence of myelin-forming cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691879
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The interaction of Schwann cells with CNS axons in regions containing normal astrocytes (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 295-300 
    Details
    ISSN: 1432-0533
    Keywords: CNS ; PNS ; Demyelination ; Schwann cells ; Astrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On occasions retinal axons can be myelinated elinated by Schwann cells. In the present experiments cultured autologous Schwann cells were injected into the optic disc of adult cats and the extent of Schwann cell myelination determined. Little if any Schwann cell myelination of retinal ganglion cell axons developed. Schwann cells were also injected into lesions in the cerebral cortex induced by ethidium bromide. In this site some Schwann cell remyelination was detected, but it was restricted to areas next to regions of malacia induced by the injection procedure. It was concluded that astrocyte responses, limit Schwann cell myelination and remyelination in normal tissue by excluding Schwann cells from the CNS compartment, and induce changes in chronically demyelinated and amyelinated axons which may affect myelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688052
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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