ISSN:
1432-1912
Keywords:
Asymmetric Behaviour
;
Dopamine Agonists
;
Piribedil Metabolites
;
Intrastriatal Injections
;
Stereotyped Behaviour
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The intrastriatal injection technique was used to determine whether the behavioural effects observed after peripherally administered piribedil which are attributable to dopaminergic stimulation and predictive of antiparkinson potential, are initiated by the parent compound or by a metabolite (S.3473, S.575, S.584). Asymmetric behaviour and stereotypy were used as indices of dopaminergic stimulation following unilateral and bilateral intrastriatal injections respectively and comparisons were made with the actions of dopamine and known dopamine agonists (apomorphine, d- and l-amphetamine, amantadine, methylphenidate). The neostriatum was shown to be generally insensitive to the application of these agents in saline pretreated rats, responses being obtained only following the injection of large doses of dopamine, d-amphetamine, methylphenidate and S.584. These responses were enhanced in the presence of nialamide or nialamide/atropine but piribedil and its metabolites, other than S.584, were inactive. A dopamine-like activity for S.584 (but not for parent piribedil, S.3473 or S.575) was further indicated in experiments where the neostriatal dopamine threshold was reduced by the peripheral administration of dopamine agonist, and confirmed in a ‘model’ utilising a monoamine oxidase inhibitor/neuroleptic pretreatment regime in which intrastriatal dopamine induced marked contralateral asymmetries which were mimicked by S.584. It is suggested that S.584 may represent the active component mediating the dopamine ‘stimulant’ effects observed after peripherally administered piribedil.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00499528
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