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  • Ataxia  (2)
  • Exploratory behavior  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Behavioral effects of alpha2 adrenoceptor antagonists and their interactions with ethanol in tests of locomotion, exploration and anxiety in mice (1989)
    Springer
    Psychopharmacology 97 (1989), S. 189-193 
    Details
    ISSN: 1432-2072
    Keywords: Alpha2-adrenoceptors ; Ethanol ; Anxiety ; Exploratory behavior ; Locomotor activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioral effects of two highly selective alpha2-adrenoceptor antagonists, atipamezole and idazoxan, were investigated in mice using the plusmaze test of anxiety and the holeboard test of directed exploration and locomotor activity. No anxiogenic effect, as assessed by the tendency to enter the closed as opposed to open arms of the plusmaze, was noted for either drug at any dose tested. Neither were there any significant effects on locomotor activity or directed exploration (head-dipping) in the holeboard, or total plusmaze arm entries at any dose of either drug. The co-administration of either atipamezole or idazoxan had no effect on either the anxiolytic effect of ethanol (2 g/kg) or its locomotor stimulant effect in the holeboard. Atipamezole (1.0 and 3.0 mg/kg) significantly reversed the ethanol-induced reduction in exploratory head-dipping; a similar trend was seen for idazoxan. There was also a significant potentiation of the ethanol-induced increase in the number of total arm entries made on the plusmaze caused by 1.0 mg/kg (but not 3.0 mg/kg) atipamezole and both 0.3 and 1.0 mg/kg idazoxan. The results suggest that some of the behavioral effects of ethanol can be reversed by alpha2-adrenoceptor antagonists whilst others are unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442248
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interactions of intracerebroventricular pertussis toxin treatment with the ataxic and hypothermic effects of ethanol (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 344 (1991), S. 252-258 
    Details
    ISSN: 1432-1912
    Keywords: Pertussis toxin ; Pertussis toxin B-oligomer ; G-proteins ; Ethanol ; Ataxia ; Hypothermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pretreatment with pertussis toxin (0.5 and 1.0 μg/animal, i. c. v., seven days prior to testing) reversed the reduction in locomotor activity in the holeboard test caused by administration of the alpha2-adrenoceptor agonist, medetomidine (0.1 mg/kg, i. p.). Intrinsic behavioral effects of pertussis toxin treatment were also observed, these included a reduction in exploratory head-dipping and an increase in locomotor activity. These doses of pertussis toxin also reduced the ataxia induced by a 2.4 g/kg dose of ethanol. Pertussis toxin treated animals also exhibited a diminished hypothermic response to ethanol (2 g/kg), although the pertussis toxin treated animals had lower body temperatures prior to ethanol administration compared to sham treated animals. Neither the behavioral effect of pertussis holotoxin in the holeboard nor its effects on reversing medetomidine hypolocomotion or ethanol-induced ataxia were seen following administration of the binding oligomer of pertussis toxin which binds to the cell membrane but does not possess the enzymatically active subunit. These findings implicate mechanisms involving pertussis toxin sensitive G-proteins in modulating some behavioral and physiological effects of ethanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167227
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol (1990)
    Springer
    Psychopharmacology 101 (1990), S. 196-202 
    Details
    ISSN: 1432-2072
    Keywords: Phenylethanolamine-N-methyltransferase (PNMT) ; Ethanol ; Locomotion ; Exploration ; Anxiety ; Ataxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The centrally active inhibitors of phenylethanolamine-N-methyltransferase (PNMT), LY 78335 and LY 134046, were investigated both alone and in combination with ethanol (2 g/kg) in a holeboard test of directed exploration and locomotor activity. Both PNMT inhibitors showed dose-related reductions in exploratory head-dipping but were without effect on locomotor activity. In combination with ethanol both PNMT inhibitors tended to attenuate the ethanol-induced reductions in exploratory head-dipping but did not effect ethanol's locomotor stimulant properties. LY 134046 showed neither an anxiolytic nor an anxiogenic profile in the plusmaze test of anxiety, nor did it alter the anxiolytic effects of either 1.2 g/kg or 2 g/kg ethanol. LY 134046 did, however, attenuate the ataxic effects of a 2.4 g/kg dose of ethanol. These results may suggest a role for adrenaline synthesis in some, but not all, of the behavioral effects of ethanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244126
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    Paper (German National Licenses)
    Fulltext
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