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  • 1
    Electronic Resource
    Electronic Resource
    Functional evidence against the existence of β2-adrenoceptors mediating positive inotropic effects in guinea-pig right ventricular myocardium (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 355 (1996), S. 74-78 
    Details
    ISSN: 1432-1912
    Keywords: Key wordsβ1-adrenoceptor ; β2-adrenoceptor ; Guinea-pig ventricular myocardium ; Positive inotropic effect ; Atenolol ; ICI 118.551
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In guinea-pig isolated papillary muscles we studied the positive inotropic effects of the β-adrenoceptor agonists isoprenaline, fenoterol and noradrenaline in the presence and absence of the β1-selective antagonist atenolol and the β2-adrenoceptor antagonist ICI 118.551. In Schild regression analysis pA2 values for either atenolol (7.14–7.16) and ICI 118.551 (6.79–6.84) were independent of the agonists used. These results support the view that the inotropic response in guinea-pig ventricular myocardium is mediated by β1-adrenoceptors only.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00004920
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of expression kinetics and activity of a new B-domain truncated and full-length FVIII protein in three different cell lines (1999)
    Springer
    Annals of hematology 78 (1999), S. 111-116 
    Details
    ISSN: 1432-0584
    Keywords: Key words FVIII ; B-domain ; Transient expression ; Specific activity ; Cell type specific
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Transient expression of full-length wild-type (wt) and a new B-domain truncated (ΔB) FVIII has been investigated in three eukaryotic cell lines (HEK-293, COS, CHO). When expressed in CHO cells, both FVIII proteins reached the same peak antigen levels, whereas in HEK-293 and COS cells those of FVIII/ΔB were up to sixfold those of FVIII/wt. Investigation of specific activity of the recombinant FVIII proteins using a chromogenic and a one-stage assay in addition to the FVIII-antigen ELISA revealed large variations: In HEK-293 cells specific activity of FVIII/ΔB measured with both assays was higher than that of FVIII/wt. In COS cells specific activity of both FVIII proteins was higher measured in the one-stage assay than in the chromogenic assay. In CHO cells both FVIII proteins had similar specific activity in each assay. In summary, expression kinetics and specific activity of conditioned medium vary depending on cell type used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050486
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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