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  • Atmospheric Pollution  (1)
  • Humidifier disease  (1)
  • Methanol dehydrogenase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Precipitating antibodies and positive skin tests in workers exposed to airborne antigens from a contaminated humidification system (1989)
    Springer
    International archives of occupational and environmental health 61 (1989), S. 547-553 
    Details
    ISSN: 1432-1246
    Keywords: Humidifier disease ; Skin test ; Serology ; Smoking habits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Precipitating antibodies and positive skin tests to antigens from a contaminated humidification system in a synthetic carpet yarn plant were tested in a group of exposed (n =66) and non-exposed (n = 45) workers. The first investigation was carried out in 1979 shortly before hygienic actions to reduce exposure had been taken. In 1981 and 1985 they were repeated. The significant difference between the positive skin reactions and of positive serology (4 or more lines), observed in 1979 between the exposed and non-exposed population, was not found in 1981 and 1985. In 1979 the differences were the most pronounced in the non-smoking individuals. However, even in that category the significant difference disappeared in 1981 and 1985. A positive skin test in 1979 did not increase the chance of having a positive skin test during repeat investigations. In serology this was only the case when the positive criterion was lowered to three or more lines. This study demonstrates that, in the absence of a quantitative analysis of airborne antigens, skin tests and serology may be helpful in obtaining an estimation of antigenic contamination of the air and subsequent sensitization on a group level. However, these tests are less appropriate when used in an individual health surveillance program at this type of nonspecific antigen exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00683125
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Epidemiological investigations in the Netherlands into the influence of smoking and atmospheric pollution or respiratory symptoms and lung function disturbances (1973)
    Springer
    Lung 149 (1973), S. 119-126 
    Details
    ISSN: 1432-1750
    Keywords: Atmospheric Pollution ; Lung Function Disturbances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Results of epidemiological cross-sectional studies of chronic non-specific lung diseases (CNSLD) in the Netherlands suggest that the exogenous factors smoking and atmospheric pollution have an effect on chronic production of phlegm. These factors seemed to have no effect on bronchial obstruction, except in one subgroup of men, in whom there was a relationship between the exogenous factors and the prevalence of dyspnoea, although no relationship was found between these factors and impairment of FEV1. The implications of the findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151747
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Environmental regulation of alcohol metabolism in thermotolerant methylotrophic Bacillus strains (1992)
    Springer
    Archives of microbiology 157 (1992), S. 272-278 
    Details
    ISSN: 1432-072X
    Keywords: Bacillus ; Thermotolerance ; Methylotrophy ; Methanol dehydrogenase ; Activator protein ; RuMP cycle of formaldehyde fixation ; Hexulose-6-phosphate synthase ; Continuous culture ; Methanol limitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The thermotolerant methylotroph Bacillus sp. C1 possesses a novel NAD-dependent methanol dehydrogenase (MDH), with distinct structural and mechanistic properties. During growth on methanol and ethanol, MDH was responsible for the oxidation of both these substrates. MDH activity in cells grown on methanol or glucose was inversely related to the growth rate. Highest activity levels were observed in cells grown on the C1-substrates methanol and formaldehyde. The affinity of MDH for alcohol substrates and NAD, as well as V max, are strongly increased in the presence of a M r 50,000 activator protein plus Mg2+-ions [Arfman et al. (1991) J Biol Chem 266: 3955–3960]. Under all growth conditions tested the cells contained an approximately 18-fold molar excess of (decameric) MDH over (dimeric) activator protein. Expression of hexulose-6-phosphate synthase (HPS), the key enzyme of the RuMP cycle, was probably induced by the substrate formaldehyde. Cells with high MDH and low HPS activity levels immediately accumulated (toxic) formaldehyde when exposed to a transient increase in methanol concentration. Similarly, cells with high MDH and low CoA-linked NAD-dependent acetaldehyde dehydrogenase activity levels produced acetaldehyde when subjected to a rise in ethanol concentration. Problems frequently observed in establishing cultures of methylotrophic bacilli on methanol- or ethanol-containing media are (in part) assigned to these phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00245161
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    Paper (German National Licenses)
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