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  • Atmospheric Pollution  (1)
  • Humidifier fever  (1)
  • Methanol dehydrogenase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Lung function of workers exposed to antigens from a contaminated air-conditioning system (1985)
    Springer
    International archives of occupational and environmental health 55 (1985), S. 253-266 
    Details
    ISSN: 1432-1246
    Keywords: Humidifier fever ; Lung function ; Skin test ; Serology ; Smoking habits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following the manifestation of humidifier fever in a number of workers in a carpet yarn texturing plant, a comparative study was begun of a group of workers exposed to fungi from the air-conditioning system and a control group not so exposed. For both group of workers anamnestic data were collected, intracutaneous skin tests were performed, certain lung function parameters were determined, and the presence of antibodies to a number of antigens from the system was tested for. It was found that the group of exposed workers had a significantly higher rate of positive intracutaneous skin test than non-exposed workers. Additionally, their serology was more often positive. Both positive skin test and positive serology were more frequent in non-smokers than in smokers. A positive immediate skin reaction among exposed workers was found to correlate with an FEF25–75 reduction during the working week. A positive delayed skin reaction among exposed workers correlated with a lower FVC prior to the start of the working week than recorded for non-exposed workers. A positive serology in exposed workers did not correlate with a difference in lung function compared with non-exposed workers, nor was there a correlation with a change in lung function in the course of the working week. When humidifier fever is diagnosed, steps should be taken to reduce exposure. It would also appear desirable to keep exposed workers under medical observation and to monitor the subsequent development of their lung function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00383758
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Epidemiological investigations in the Netherlands into the influence of smoking and atmospheric pollution or respiratory symptoms and lung function disturbances (1973)
    Springer
    Lung 149 (1973), S. 119-126 
    Details
    ISSN: 1432-1750
    Keywords: Atmospheric Pollution ; Lung Function Disturbances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Results of epidemiological cross-sectional studies of chronic non-specific lung diseases (CNSLD) in the Netherlands suggest that the exogenous factors smoking and atmospheric pollution have an effect on chronic production of phlegm. These factors seemed to have no effect on bronchial obstruction, except in one subgroup of men, in whom there was a relationship between the exogenous factors and the prevalence of dyspnoea, although no relationship was found between these factors and impairment of FEV1. The implications of the findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151747
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Environmental regulation of alcohol metabolism in thermotolerant methylotrophic Bacillus strains (1992)
    Springer
    Archives of microbiology 157 (1992), S. 272-278 
    Details
    ISSN: 1432-072X
    Keywords: Bacillus ; Thermotolerance ; Methylotrophy ; Methanol dehydrogenase ; Activator protein ; RuMP cycle of formaldehyde fixation ; Hexulose-6-phosphate synthase ; Continuous culture ; Methanol limitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The thermotolerant methylotroph Bacillus sp. C1 possesses a novel NAD-dependent methanol dehydrogenase (MDH), with distinct structural and mechanistic properties. During growth on methanol and ethanol, MDH was responsible for the oxidation of both these substrates. MDH activity in cells grown on methanol or glucose was inversely related to the growth rate. Highest activity levels were observed in cells grown on the C1-substrates methanol and formaldehyde. The affinity of MDH for alcohol substrates and NAD, as well as V max, are strongly increased in the presence of a M r 50,000 activator protein plus Mg2+-ions [Arfman et al. (1991) J Biol Chem 266: 3955–3960]. Under all growth conditions tested the cells contained an approximately 18-fold molar excess of (decameric) MDH over (dimeric) activator protein. Expression of hexulose-6-phosphate synthase (HPS), the key enzyme of the RuMP cycle, was probably induced by the substrate formaldehyde. Cells with high MDH and low HPS activity levels immediately accumulated (toxic) formaldehyde when exposed to a transient increase in methanol concentration. Similarly, cells with high MDH and low CoA-linked NAD-dependent acetaldehyde dehydrogenase activity levels produced acetaldehyde when subjected to a rise in ethanol concentration. Problems frequently observed in establishing cultures of methylotrophic bacilli on methanol- or ethanol-containing media are (in part) assigned to these phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00245161
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    Paper (German National Licenses)
    Fulltext
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