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  • 1
    Electronic Resource
    Electronic Resource
    Possible pathogenic role of IgE in Henoch-Schönlein purpura (1994)
    Springer
    Pediatric nephrology 8 (1994), S. 169-171 
    Details
    ISSN: 1432-198X
    Keywords: Atopy ; IgA nephropathy ; Henoch-Schönlein purpura ; IgE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidences of clinical and biological markers of atopy were investigated in 16 children with IgA nephropathy (IgAN) (group A) and in 22 with Henoch-Schönlein purpura nephritis (HSPN) (group B). The incidence of increased plasma IgE levels according to age-matched normal values was significantly higher in group B (17/22, 77%) than in group A (7/16, 44%) (P〈0.05). Although not significant, the incidences of positive RAST tests and of a history of typical atopic symptoms were also higher in group B [10/22 (45%) and 11/22 (50%), respectively] than in group A [4/16 (25%) and 5/16 (31%), respectively]. Moreover, IgE deposits were demonstrated by a peroxidase/anti-peroxidase method on cutaneous Langerhans and mast cells in 4 of 6 patients with HSPN. Thus immunoallergy might account, in some cases, for the cutaneous, intestinal and pulmonary signs observed in HSPN, but not in IgAN. We postulate stimulation of IgE-sensitized mast cells by specific antigens in the presence of IgA circulating immune complexes (CIC), release of vasoactive substances, increased capillary permeability and perivascular deposition of IgA CIC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00865470
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  • 2
    Electronic Resource
    Electronic Resource
    Displacement and spacer displacement chromatography. Alteration of spot profile in displacement thin-layer chromatography (1989)
    Springer
    Chromatographia 27 (1989), S. 253-256 
    Details
    ISSN: 1612-1112
    Keywords: Displacement chromatography ; Displacement TLC ; Overloaded elution chromatography ; Spacer displacement thin-layer chromatography ; Spot profile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Migration of spots in displacement development was investigated using a planar stationary phase. The effects of the presence or absence of the additive substances in the carrier were demonstrated when these compounds also played a role in the competition for the binding sites of the stationary phase; however, they were not members of the displacement train. In the case of displacement chromatography, compounds A+B are well separated but located very closely to each other. Using a spacer (C) in the sample, the peaks or spots of A and B are aparted by C and their virtual separation is increased. When compounds A+B were displaced by each other as well as by the displacer, the presence of the additive compound C in the carrier (carrier-spacer) can transfer an otherwise displaced component (A) into the so-called overloaded elution region of the chromatogram. At the same time the additive compound C does not unconditionally reduce the performance of displacement chromatography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260457
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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