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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 6 (1970), S. 220-226 
    ISSN: 1432-0827
    Keywords: Hypercalcemia ; Hypocalcemia ; Adrenal Cortex ; Hormones ; Secretion ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Les augmentations en teneur du calcium plasmatique, provoquées par le gluconate de calcium, donnent des taux de sécrétions plus élevées du cortex surrénalien chez les chiens anesthésiés. L'hypocalcémie consécutive à l'action du EDTA n'a pas d'action sur ces sécrétions et l'hypophysectomie supprime l'augmentation des taux de sécrétion, observés chez l'animal entier hypercalcémique. Les mécanismes par lesquels le calcium peut affecter les sécrétions cortico-surrénaliennes sont envisagés en fonction des effects au niveau des différentes phases du système hypothalamo-hypophyso-cortico-surrénalien.
    Abstract: Zusammenfassung Durch Infusion von Calciumgluconat verursachte Erhöhungen des Plasmacalciumspiegels ergaben beim anaesthesierten Hund eine gesteigerte adrenocorticale Sekretion. Die Hypocalcämie, die auf Grund von EDTA-Infusion entstand, hatte keine sichtbare Wirkung auf das Ausmaß der adrenocorticalen Sekretion. Durch Hypophysektomie wurde die gesteigerte Sekretion, wie man sie beim hypercalcaemischen Tier findet, aufgehoben. Die Mechanismen, durch welche Calcium die adrenocorticale Sekretion beeinflussen kann, werden im Hinblick auf seine Wirkung an verschiedenen Stellen im hypothalamo-hypophysär-adrenocorticalen System besprochen.
    Notes: Abstract Increases in plasma calcium levels caused by the infusion of calcium gluconate resulted in enhanced adrenocortical secretory rates in anesthetized dogs. Hypocalcemia resulting from the infusion of EDTA had no discernible effect on adrenocortical secretory rates, and hypophysectomy abolished the rise in secretory rates noted in the hypercalcemic intact animals. The mechanisms by which calcium may effect adrenocortical secretion are discussed with respect to its effect at various sites in the hypothalamo-hypophyseal-adrenocortical system.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 39 (1990), S. 589-591 
    ISSN: 1432-1041
    Keywords: Atrial natriuretic factor (ANF) ; platelet aggregation ; aldosterone ; whole blood ; ex-vivo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol·kg−1.min−1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6–2 μg·ml−1)-induced or ADP (0.5–2.0 μM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperreactivity, often observed in these conditions.
    Type of Medium: Electronic Resource
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